Synthesis, Characterization and Antibacterial Activity of Cefalexin Dervatives Entesar O. AL-Tamimi| Raad M. Muslih| Khalida A.Thejeel

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Baghdad Science Journal

Abstract

New series of Schiff bases 2(a-j) and corresponding beta-lactam derivatives 3(a-j) were synthesized from cefalexin (1) as starting material. The compound (1) was reacted with different aldehydes and ketones to give Schiff bases derivatives 2(a-j). The synthesized Schiff bases were cyclized by chloroacetyl chloride in the presence of triethylamine to form beta-lactam derivatives 3(a-j). The compounds were characterized by deremination melting point, FT-IR and 1H NMR. The beta-lactam derivatives were screened in vitro antibacterial against some bacterial species

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Journal BS. Synthesis, Characterization and Antibacterial Activity of Cefalexin Dervatives. BSJ [Internet]. 6Sep.2015 [cited 9Aug.2020];12(3):546-54. Available from: http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2099
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