Synthesis and Characterization of Some New Pyrazoline and Isoxazoline Derivatives as Antibacterial Agents Ali K. Alywee Al-Naseeri

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Baghdad Science Journal

Abstract

In this paper some chalcones (C1-C8) are prepared based on the reaction of one mole of substituted acetophenone with one mole of substituted benzaldehydes in the presence of (40%) sodium hydroxide as a base. Pyrazolines (P1–P8) are prepared from the reaction of chalcones (C1-C8) with hydrazine hydrate.
Isoxazoline (I1-I8) is prepared from the reaction of chalcones (C1-C8) with hydroxyl amine hydrochloride in the presence of (10%) sodium hydroxide as a base. These compounds are characterized by using various physical and spectral methods. The compounds are screened for their in vitro antibacterial activity using gram-positive bacteria and gram-negative bacteria. Several derivatives of pyrazolines and isoxazolines are produced well to moderate activities against number of bacteria.

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Journal BS. Synthesis and Characterization of Some New Pyrazoline and Isoxazoline Derivatives as Antibacterial Agents. BSJ [Internet]. 4Sep.2016 [cited 12Aug.2020];13(3):0568. Available from: http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2300
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