Synthesizing, Characterizing and Studying the Biological Activity of Some New Schiff-Bases Derivatives Containing the Monosaccharide Moiety Amina. A. Fayad

Main Article Content

Baghdad Science Journal

Abstract

A new series of ?-D-glucose as Schiff bases derivatives is synthesized and characterized with studying their bioactivity. Hydroxyl groups at C (1,2&5,6) sugar moiety are converted into acetal form through a reaction with dry acetone using phosphoric acid and anhydrous zinc chloride as catalysts producing 1,2:5,6-di-O-isopropyledine ?-D-glucofuranose(I). The five memberd ring acetal of C(5,6) is hydrolyzed with acetic acid (65%)and a reaction of the new product with sodium periodate is carried on to get an aldehyde moiety which is used to produce a new series of Schiff bases through reacting with different amino compounds such as 4-amino antipyrene .
The suggested chemical structures of the prepared compounds are confirmed by using UV., FT-IR and1 H-NMR spectra .Most of the prepared compounds show antibacterial activity.

Downloads

Download data is not yet available.

Article Details

How to Cite
1.
Journal BS. Synthesizing, Characterizing and Studying the Biological Activity of Some New Schiff-Bases Derivatives Containing the Monosaccharide Moiety. BSJ [Internet]. 4Sep.2016 [cited 5Aug.2020];13(3):0578. Available from: http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2301
Section
article

Most read articles by the same author(s)

1 2 3 4 5 6 7 8 9 10 > >>