Synthesizing, Characterizing and Studying the Biological Activity of Some New Schiff-Bases Derivatives Containing the Monosaccharide Moiety

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Amina. A. Fayad

Abstract

A new series of ?-D-glucose as Schiff bases derivatives is synthesized and characterized with studying their bioactivity. Hydroxyl groups at C (1,2&5,6) sugar moiety are converted into acetal form through a reaction with dry acetone using phosphoric acid and anhydrous zinc chloride as catalysts producing 1,2:5,6-di-O-isopropyledine ?-D-glucofuranose(I). The five memberd ring acetal of C(5,6) is hydrolyzed with acetic acid (65%)and a reaction of the new product with sodium periodate is carried on to get an aldehyde moiety which is used to produce a new series of Schiff bases through reacting with different amino compounds such as 4-amino antipyrene .
The suggested chemical structures of the prepared compounds are confirmed by using UV., FT-IR and1 H-NMR spectra .Most of the prepared compounds show antibacterial activity.

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Synthesizing, Characterizing and Studying the Biological Activity of Some New Schiff-Bases Derivatives Containing the Monosaccharide Moiety. Baghdad Sci.J [Internet]. 2016 Sep. 4 [cited 2024 Mar. 28];13(3):0578. Available from: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2301
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How to Cite

1.
Synthesizing, Characterizing and Studying the Biological Activity of Some New Schiff-Bases Derivatives Containing the Monosaccharide Moiety. Baghdad Sci.J [Internet]. 2016 Sep. 4 [cited 2024 Mar. 28];13(3):0578. Available from: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2301

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