Synthesis and Characterization of Some New Morpholine Derivatives

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Entesar O. AlTamiemi
Sameaa J. Khammas
Sura S. AlKaissi

Abstract

In this paper a new series of morpholine derivatives was prepared by reacting the morpholine with ethyl chloro acetate in the presence triethylamine as a catalyst in benzene gave morpholin-N-ethyl acetate(1) which reacted with hydrazine hydrate in ethanol, and gave morpholin-N-ethyl acetohydrazide (2) . Morpholin-N-aceto semithiocarbazide (3) were prepared by reacting compound(2) with ammonium thiocyanate , concentrated hydrochloric acid and ethanol as a solvent .Compound (3) reacted with sodium hydroxide and hydrochloric acid to give 5-(morpholin-N-methylene)-1H-1,2,4-triazole-3-thiol (4) .The new series of 1,2,4-triazol derivatives (5-8) was synthesized by reaction of compound(4) with formaldehyde , DMF as a solvent and different secondary amines. Preparation of new 1,2,4-triazoline derivatives (9) by reaction compound (4) with bromo acetic acid . Reaction of compound (9) with different aromatic aldehyde and dimethyl sulfoxide as a solvent obtained compounds (10-13).

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Synthesis and Characterization of Some New Morpholine Derivatives. Baghdad Sci.J [Internet]. 2016 Jun. 5 [cited 2024 Mar. 28];13(2.2NCC):0253. Available from: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2771
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How to Cite

1.
Synthesis and Characterization of Some New Morpholine Derivatives. Baghdad Sci.J [Internet]. 2016 Jun. 5 [cited 2024 Mar. 28];13(2.2NCC):0253. Available from: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2771

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