Synthesis of New Some Imidazole Derivatives Containing ?-Lactam Ring Firyal Waly Askar | Rana Abid Ali | Thanaa Mahdi Al-Mouamin

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Baghdad Science Journal

Abstract

In this work 5-methylene-yl - (2-methy –oxazole-4-one) (1H) imidazole (1) were synthesized from the reaction of L-Histidine with acetic anhydride and which converted to the of 5-methylene-yl-(2-methyl 3-amino imidazole-4-one)-1H-imidazole (2) by reaction with hydrazine hydrate. Schiff bases (3-6) were synthesized from the reaction of compound (2) with different aromatic aldehyde. Reaction of compounds (3-6) with chloroacetyl chloride gives azetidinone one derivatives (7-10). These compounds were characterized by FT-IR and some of them with 1H-NMR and 13C-NMR spectroscopy.

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Journal BS. Synthesis of New Some Imidazole Derivatives Containing ?-Lactam Ring. BSJ [Internet]. 5Jun.2016 [cited 3Aug.2020];13(2.2NCC):0307. Available from: http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2776
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