Synthesis of New N-Substituted Phenoxazine Derivatives sraa Taha Ibraheem | sraa Taha Ibraheem

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Baghdad Science Journal


This work comprises the synthesis of new phenoxazine derivatives containing N-substituted phenoxazine starting from phenoxazine (1). Synthesis of ethyl acetate phenoxazine (2) through the reaction of phenoxazine with ethylchloroacetate, which reacted with hydrazine hydrate to give 10-aceto hydrazide phenoxazine (3), then reacted with formic acid to give 10-[N-formyl acetohydrazide] phenoxazine (4). Reaction of compound (4) with phosphorous pentaoxide or phosphorus pentasulphide to gave 10-[N-methylene-1,3,4-oxadiazole] phenoxazine (5) and 10-[N-methylene-1,3,4-thiadiazole] phenoxazine (6).


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Journal BS. Synthesis of New N-Substituted Phenoxazine Derivatives. BSJ [Internet]. 5Jun.2016 [cited 3Aug.2020];13(2.2NCC):0360. Available from:

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