PREPARATION OF NITRATION DERIVATIVES OF BILE SALTS AND ACIDS FOR MEDICAL USE

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s. M. Dhaher
A. Al-Rawi
S. A. Abbas

Abstract

The derivatives formed after the successive acetylation, esterification and nitration reactions to cholic, deoxycholic, and taurocholic acids were identified to be of the following general strucure: Colt, Where RI=NO3, OH, 0=, or CH3COO. R2=H, NO3, OH, 0-=, or CH3COO. R3=H, NO3,01-1, 0=, or CH3COO. R4=OH, NH(CH2)2S03Na, NH(CH2)2S03H, or OMe. By using U.V-visible and I.R spectrophotometry . The number of hydroxyl groups was determined, purity was checked from T.L.C, Most of these derivatives will find pharmaceutical application.

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PREPARATION OF NITRATION DERIVATIVES OF BILE SALTS AND ACIDS FOR MEDICAL USE . Baghdad Sci.J [Internet]. 2021 Mar. 8 [cited 2024 Mar. 28];1(2):174-9. Available from: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/544
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How to Cite

1.
PREPARATION OF NITRATION DERIVATIVES OF BILE SALTS AND ACIDS FOR MEDICAL USE . Baghdad Sci.J [Internet]. 2021 Mar. 8 [cited 2024 Mar. 28];1(2):174-9. Available from: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/544