Synthesis, Characterization of Chitosan para- hydroxyl Benzaldehyde Schiff Base Linked Maleic Anhydride and the Evaluation of Its Antimicrobial Activities
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Abstract
Current research included preparation, characterization of some new chitosan- hydroxy benzaldehyde-Schiff bases with maleic anhydride. The present study aimed to the synthesis and characterization of novel chitosan Schiff base compounds using para- hydroxy benzaldeh and maleic anhydride. The derivative of the schiff-chitosan base, which is associated with different drugs, has been replaced with different amino and hydroxy drugs. The derivative is characterized by different analytical techniques. The results of FT-IR studies clearly indicate construction of the chief amine group in chitosan and the emergence of new bands that correspond to the association of maleic anhydride with the chitosan base. TGA, 1H-NMR, biological studies acquired two types of bacteria Gram +ve (Bacillus, Staphylococcus aureus) and two bacteria Gram -ve (Escherichia coli, Pseudomonas aeruginosa) and yeast like fungi (Candida albicans).
Received 13/10/2020
Accepted 17/10/2021
Published Online First 20/5/2022
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Islam S, Bhuiyan MR, Islam MN. Chitin and chitosan: structure, properties and applications in biomedical engineering. J Polym Environ. 2017 Sep; 25(3 ): 854-66.
Jafari Z, Rad AS, Baharfar R, Asghari S, Esfahani MR. Synthesis and application of chitosan/tripolyphosphate/graphene oxide hydrogel as a new drug delivery system for Sumatriptan Succinate. J Mol Liq. 2020 Oct 1; 315: 113835..
Paul P, Kolesinska B, Sujka W. Chitosan and its derivatives-biomaterials with diverse biological activity for manifold applications. Mini Rev Med Chem. 2019 Jun 1; 19(9): 737-50..
Lipatova IM, Yusova AA, Losev NV, Indeikin EA. Gelation in solutions of low deacetylated chitosan initiated by high shear stresses. Int J Biol Macromol. 2019 Oct 15; 139: 550-7..
Ahsan SM, Thomas M, Reddy KK, Sooraparaju SG, Asthana A, Bhatnagar I. Chitosan as biomaterial in drug delivery and tissue engineering. Int J Biol Macromol. 2018 Apr 15; 110: 97-109..
Eldin MM, Hashem AE, Tamer TM, Omer AM, Yossuf ME, Sabet MM. Development of cross linked chitosan/alginate polyelectrolyte proton exchanger membranes for fuel cell applications. Int J Electrochem Sci . 2017 May 1; 12: 3840-58.
Bakshi PS, Selvakumar D, Kadirvelu K, Kumar NS. Chitosan as an environment friendly biomaterial–a review on recent modifications and applications. Int J Biol Macromol . 2020 May 1; 150: 1072-83.
Divya K, Pinto GM, Pinto AF. Application of metal complexes of Schiff bases as an antimicrobial drug: a review of recent works. Int J Curr Pharm Res. 2017; 9(3): 27-30.
Elhag M, Abdelwahab HE, Mostafa MA, Nasr AZ, El Sadek MM. Synthesis and characterization of chitosan-pyrazoloquinoxaline Schiff bases for Cr (VI) removal from wastewater. Int J Biol Macromol. 2020 Nov 15; 163: 2180-8..
Kurita K, Mori S, Nishiyama Y, Harata M. N-Alkylation of chitin and some characteristics of the novel derivatives. Polym Bull. 2002 Apr; 48(2): 159-66.
Anicuta SG, Dobre L, Stroescu M, Jipa I. Fourier transform infrared (FTIR) spectroscopy for characterization of antimicrobial films containing chitosan. Analele Univ din Oradea Fasc. Biol. 2010: 815-822.
Wanule D, Balkhande JV, Ratnakar PU, Kulkarni AN, Bhowate CS. Extraction and FTIR analysis of chitosan from American cockroach, Periplaneta americana. Int J Eng Sci Tech. 2014 May;3(3):299-304.
Alsahib SA. Characterization and Biological Activity of Some New Derivatives Derived from Sulfamethoxazole Compound. Baghdad Sci.J. 2020;17(2):471-480.
Kritchenkov AS, Egorov AR, Artemjev AA, Kritchenkov IS, Volkova OV, Kiprushkina EI, Zabodalova LA, Suchkova EP, Yagafarov NZ, Tskhovrebov AG, Kurliuk AV. Novel heterocyclic chitosan derivatives and their derived nanoparticles: Catalytic and antibacterial properties. Int J Biol Macromol. 2020 Apr 15; 149: 682-92.
Ali AT, Mosa MN, Alshaheen ZG, Muhammad-Ali MA. Synthesis, characterization and antibacterial evaluation of oxoazetidin benzene sulfonamide derivatives as a hybrid antimicrobial agents. Syst. Rev. Pharm. 2020 Feb 1; 11(2): 487-94..
El-Naggar NE, Deraz SF, El-Ewasy SM, Suddek GM. Purification, characterization and immunogenicity assessment of glutaminase free L-asparaginase from Streptomyces brollosae NEAE-115. BMC Pharmacol Toxicol. 2018 Dec; 19(1): 1-5.
Rajesh Kumar S, Ma WT, Lu HC, Teng LW, Hsu HC, Shih CM, Yang CC, Lue SJ. Surfactant-assisted perovskite nanofillers incorporated in quaternized poly (vinyl alcohol) composite membrane as an effective hydroxide-conducting electrolyte. Energies. 2017 May;10(5):615.
Ahmood Kh.Jebur Al-Joubory. Synthesis, Characterization and Biological Activity Evaluation of Some Pyrazoles,Thiazoles and Oxazoles Derived from 2-Mercaptaptoaniline. Baghdad Sci J. 2021;18(1).
Silverstein R. , Bassler G. ,Spectrometric identification of organic compound, 1991; 7th ed. part 4:430. John Wiley and sons ltd.
Lindon J C, Tranter G E, Holmes J L. Encyclopedia of Spectroscopy and spectrometry . 2016 ;3nd; 3584, Canada.
Field L D, Sternhell S, Kalman J R, Organic Structures from Spectra. 2008 4th ed. part 3, Australia.
Madhu N T, Radhakrishnan P K, Edna W, Linert W. Thermal decomposition studies on cobalt (II) compolexes of 4-N-antipyrylmethylidene aminoantipyrenewt hvarying counterions . J Therm Anal Calorim. 2005 ;79:157–161