Synthesis, Spectral Identification, Antibacterial Evaluationand Theoretical Study of Co, Fe, Rh and Pd Complexes for 2-benzoylthiobenzimidazol


  • Israa H. Ibraheem Department of Chemistry, College of Science for Woman, University of Baghdad, Baghdad, Iraq
  • Amaal S. Sadiq Department of Chemistry, College of Science for Woman, University of Baghdad, Baghdad, Iraq
  • Maha Al-Tameemi Department of Chemistry, College of Science for Woman, University of Baghdad, Baghdad, Iraq
  • Mahasin F. Alias Department of Chemistry, College of Science for Woman, University of Baghdad, Baghdad, Iraq



2-Benzoylthiobenzimidazole, Dipole moment, Metal salt, Secondary ligand, Semi-empirical, Pathogenic bacteria


A new novel series of metalcomplexes are prepared from reactions between 2-benzoylthio- benzimidazole (L) with metal salts of Co (II) , Fe(III) and Rh (III) , while Pd(II) complex was obtained by mixing ligandsof 2-benzoylthiobenzimidazole (L) as primary ligand and bipyridine (L/)as secondary ligand as well as palladium chloride as metal salt in an ethanoic medium. The geometry of these compounds were identified using C.H.N.microanalysis, Ultraviolet–visible, Fourier transforms infrared, magnetic susceptibility, molar conductivity and flame atomic absorption (A.A). From the dataobtained by these spectral analyses, the molecular structures for Rh and Fe complexes were proposed to be octahedral geometry. A square planar construction is proposed for Pd(II), while a Tetrahedral Geometry for Cobalt (II)complex. All of the complexes which were prepared displayedobviousconstancy and could be stored for months without showing any considerablealteration. Semi-empirical methods (ZINDO/1, ZINDO/S & PM3) were conducted to assess the heat of formation ∆H˚f, binding energy ∆Eb, and dipole moment for all compounds as theoretic study. The complexes expressnotable biological activities to pathogenic bacteria when inspected on certain bacteria. The synthesized compounds exhibited moderate toverygood antibacterial activity against bacterial strains, i.e., Escherichiacoli, Staphylococcus aureus & Pseudomonas aeruginosa.


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Amer S, El-Wa kiel N, El – Ghamry H, Synthesis,spectral, antitumor and antimicrobial studies on Cu (II) complexes of purin and triazole Schiff base derivative. J Mole Struct. 2013; 1049: 326.

Geersing A, Ségaud N, Van der Wijst M G, Rots M G, Roelfes G. Importance of metal-ion exchange for the biological activity of coordination complexes of the biomimetic ligand N4Py. Inorg Chem. 2018; 57(13), 7748-7756. ‏

Israa H I , Mahasen F A, Doaa U A , Synthesis and Bacterial Evalution of the V(IV),Cr(III) , Fe (III) And Co(II) Ions Complexes with Mixed Ligans (2-hydroxybenzaldine )-4-Aminoantiypyrine and 8-Hydroxyquinoline. ANJS. 2016; 19(3): 9-17.

Sodhi R K, Paul S, Metal Complexes in Medicine an Overview and Update from Drug Design Perspective. Cancer Ther Oncol IntJ. 2019; 14(2): 555883.

Karwan O A, Hikmat A M, Synthesis, Characterization, and Antibacterial Activity of Ni(II), Pd(II), and Pt(II) Complexes with 2- benzoylthiobenzimidazole Zanco. J Pure Appl .2020 ; 32 (2): 15-23.

Saja S A, Jawad K S, Ahmed A, Synthesis and Character of New Hetrocyclic Schiff,s Bases from Methyl 4- Hydroxybenzoate. ANJS. 2016; 19(3): 28-33.

Husain A, Varshney M, Rashid M, Mishra Ravinesh, Akhter A, Benzimidazole : A Valuable Insight into the recent Advances and Biological Activities J Pharm Rese. 2011; 4(2): 413-419.

Mahasin FA, Doaa H M, Amal SS, Complexes of Some Transition MetalWith 2-Benzoyl thiobenzimidazole and 1,10-Phenanthroline and Studing their Antibacterial Activity. Baghdad Sci J. 2016; 13(2s(Supplement)June): 84-94.

Hawraa M, Maha AL-T, Israa H, Muna S. Surfactant Cloud Point Extraction as a Procedure of Preconcentrating for Metoclopramide Determination Using Spectro Analytical Technique. Baghdad Sci J.2020; 17(1): 57-65.

Mahasn F A, Doaa H M, Synthesis, Spectral Study and Theoretical Treatment of Mixing Benzimidazole Derivatives and Phenanthroline Complexe. ANJS. 2014; 17 (3): 6056-6068.

A-Hammdani,A, Al –Zoubi W, New metal complexes N3 tridentate ligand Synthesis ,spectral studies and biological activity . spectrochim. Acta A Mole Biomol Spectrosc. 2016; 137: 75-89.

Israa H I, Preareparation and Physico-Chemical Investiga tion studies for the Mn (II) ,Ni(II) and Cu(II) metal complexes with ligand 2- hydroxybenzaldine urea . Baghdad Sci J. 2016; 13(2s(Supplement)June): 115-120.

Devi O, Basavaiah K, Vinay K, Revanasiddappa H, Sensitive spectrophotometric determination of metoclopramide hydrochloric in dosage forms and spiked human urine using vanilline. Arab J Chem. 2016; 9: S64-S72.

Kumar R, Mahiya K, Mathur P, synthesis, spectral and structural characterization of Cu(II) complexes of atridentate NNO donor Schiff base carrying apendantbenzimidazolyl arm. Ind J Chem. 2011; 50: 775-780.

Waleed A, Israa H, Synthesis and Spectral Analysis of Mn(II), Cu(II) Ni (II) and Cd(II) Complexes with Mixed Ligand containing 1,10- phenanthroline and Schiff base derived of 4- aminoantipyrine . Baghdad Sci J. 2014; 11(4): 1519-1521.

Mishra A P, Jain R K, Microwave synthesis, spectroscopic, thermal and biological significance of some transition metal complexes containing heterocyclic ligands. J Chem Pharm Res. 2010; 2(6): 51-61.

Rehab A M Al-Hassani, Synthesis, Structure, Antimicrobial activites and Theoretical Studies of Some New Trivalent Metal Complexes with Thiocarbamide Derivative. Int J Chem Tech Res. 2016; 5: 723-737.

Abdelghay A, Zaky R, Synthesis, Characterization and Anticancerous Properties of Mixed Ligand Pd(II) and Ag(I) Complexes with 2-Amino-7-Oxo-4,5,6,7-Tetrahydrobenzo[B]Thiophen-3-Carbonitril and 2,2'-Bipyridyl. Res J Pharm Biol Chem Sci. 2011; 2(1): 757-764.

Abbas A, Naser S, Sahar S, Zainab A, Preparation and Spectroscopic Studies of some Metal Ion Complexes of 2-((4-Formmyl-3-Hydroxynaphthalen-2-yl) Diazeenyl) Benzoic Acid. Baghdad Sci J. 2016; 13(2s(Supplement)June): 95-104.

Hakimi M, Alikhani M, Mashreghi M, Feizi N, Raeisi H, Mirzai Y, et al, Preparation, crystal structure and antibacterial activity.heterodinuclear complex of sd block containing sodium (I), manganese (II) and the enrofloxacinate anion. J Mole Struct. 2019; 1186: 355- 361.

Anitha C, Sumathi S, Tharmaraj P, Sheela C D, Synthesis, Characterization, and Biological Activity of Some Transition Metal Complexes Derived from Novel Hydrazone Azo Schiff Base Ligand. Inter J Inorg Chem. 2011; 14(3): 1-8. doi:10.1155/2011/493942

Agwara M O, Ndifon P T, Ndosiri N B, Paboudam A G, Yufanyi D M, Mohamadou A , Synthesis, characterization and antimicrobial activities of cobalt(II), copper(II) and zinc(II) mixed-ligand complexes containing 1,10-phenanthroline and 2,2′-bipyridine, Bull Chem Soc Ethiop. 2010; 24 (3), 383–389.