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Spectrophotometric Determination of Salbutamol Sulphate and Isoxsuprine Hydrochloride in Pharmaceutical Formulations

Authors

  • Zeena Z. Al Abdali Department of Chemistry, College of Education for Pure Science, University of Mosul, Mosul, Iraq.
  • Nagham N. Habeeb Department of Chemistry, College of Education for Pure Science, University of Mosul, Mosul, Iraq.
  • Elham S. Salih Department of Chemistry, College of Education for Pure Science, University of Mosul, Mosul, Iraq.

DOI:

https://doi.org/10.21123/bsj.2022.6902

Keywords:

Asoxsuprine hydrochloride, Evans blue dye, N-Bromosuccinamid, Salbutamol sulphate, Spectrophotometric

Abstract

A simple, sensitive and accurate spectrophotometric method has been developed for the determination of salbutamol sulphate (SAB) and isoxsuprine hydrochloride (ISX) in pure and pharmaceutical dosage. The method involved oxidation of (SAB) and (ISX) with a known excess of N-bromosuccinamid in acidic medium, and subsequent occupation of unreacted oxidant in decolorization of Evans blue dye (EB). This, in the presence of SAB or ISX was rectilinear over the ranges 1.0-12.0, 1.0-11.0 µg/mL, with molar absorptivity 4.21×104 and 2.58×104 l.mol-1.cm-1 respectively. The developed method had been successfully applied for the determination of the studied drugs in their pharmaceutical dosage resulting in a good agreement with certified value and standard addition procedure.

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