Biochemical Study on the Impact of Radiation-induced Oxidative Stress on Radiographers in the X-ray and CT-scan Departments
Keywords:Ionization radiation, Lipid profile test, Oxidative stress, Reduction, Vitamin D3
The consequences of ionizing radiation-induced oxidative stress on radiographers in X-ray and CT-scan departments utilizing several biochemical were analyzed. The study found highly considerable discrepancies in the interplay between radiation levels and gender in terms of mean Malondialdehyde (MAD), Vitamin D3 (Vit.D3), Triiodothyronine (T3), Thyroxine (T4), and High-Density Lipoprotein (HDL), but not Thyroid Stimulating Hormone (TSH), cholesterol, triglyceride (TG) and Low-Density Lipoprotein (LDL). The findings indicated that malondialdehyde is a useful biomarker for assessing oxidative stress in radiographers with exposure to ionizing radiation.
Published Online First 20/11/2022
Bamgbose BO, Suwaid MA, Kaura MA, Sugianto I, Hisatomi M, Asami J. Current status of oral and maxillofacial radiology in West Africa. Oral Radiol. 2018; 34(2):105–12.
Hickling S, Xiang L, Jones KC, Parodi K, Assmann W, Avery S, et al. Ionizing radiation-induced acoustics for radiotherapy and diagnostic radiology applications. Med Phys. 2018; 45(7): e707–21.
Nuszkiewicz J, Woźniak A, Szewczyk-Golec K. Ionizing radiation as a source of oxidative stress, the protective role of melatonin and vitamin D. Int J Mol Sci. 2020, 21(16), 5804; https://doi.org/10.3390/ijms21165804.
Brenner DJ, Richard Doll. Cancer risks attributable to low doses of ionizing radiation: Assessing what we know David. Adv Exp Med Biol. 2016 July; 930(24).
Cardis E, Vrijheid M, Blettner M, Gilbert E, Hakama M, Hill C, et al. The 15-Country Collaborative Study of Cancer Risk among Radiation Workers in the Nuclear Industry: EstimJtes of Radiation-Related Cancer Risks. Radiat Res. 2007;167(4): 396–416.
Richardson DB, Cardis E, Daniels RD, Gillies M, O’Hagan JA, Hamra GB, et al. Risk of cancer from occupational exposure to ionizing radiation: A retrospective cohort study of workers in France, the United Kingdom, and the United States (INWORKS). Br Med J. 2015; 351.
Droge W. Free radicals in the physiological control of cell function. Physiol Rev. 2002; 82(1):47–95.
Pizzino G, Irrera N, Cucinotta M., Pallio G, Mannino, F, Arcoraci, V, et al. Oxidative Stress: Harms and Benefits for Human Health. Oxid Med Cell Longev, 2017, 8416763. https://doi.org/10.1155/2017/8416763.
Frei B. Reactive oxygen species and antioxidant vitamins: Mechanisms of action. Am J Med. 1994;97(3 SUPPL. 1):5–13.
Alaaraji S, Alrawi K., Allah P; Alkrwi E. Evaluation of Serum Malondialdehyde , Glutathione and Lipid Profile Levels in Iraqi Females with Type 2 Diabetes Mellitus. Baghdad Sci J. 2016; 13 (2.2) NCC.
Dong S, Liu X, Yuan S, Wang S, Li W, Chen Z, et al. Oxidative stress: A critical hint in ionizing radiation-induced pyroptosis. Radiat Med Prot [Internet]. 2020;1(4):179–85. https://doi.org/10.1016/j.radmp.2020.10.001
Ghorbanzadeh-Moghaddam A, Gholamrezaei A; Hemati S. Vitamin D deficiency is associated with the severity of radiation-induced proctitis in cancer patients. Int J Radiat Oncol Biol Phys [Internet]. 2015; 92(3):613–8. http://dx.doi.org/10.1016/j.ijrobp.2015.02.011
Cojic, M, Kocic R, Klisic, A ; Kocic, G. The Effects of Vitamin D Supplementation on Metabolic and Oxidative Stress Markers in Patients With Type 2 Diabetes: A 6-Month Follow Up Randomized Controlled Study. Front Endocrinol. 2021 Aug. 12, 610893. https://doi.org/10.3389/fendo.2021.610893.
Chen TY, Hsu CC, Feng IJ, Wang JJ, Su SB, Guo HR, et al. Higher risk for thyroid diseases in physicians than in the general population: A Taiwan nationwide population-based secondary analysis study. Int J Med. 2017 March ;110(3):163–8.
Alawneh K, Alshehabat M, Al-Ewaidat H, Raffle L, Forihat D; Khader Y. Asymptomatic effect of occupational radiation exposure on thyroid gland hormones and thyroid gland ultrasonographic abnormalities. J Clin Med. 2018 April ;7(4):7–11.
Susan J ; Rana R, Kinetic Studies of Na+ /K+ -ATPase in Tissue Aerobic Thyroid Patients. Baghdad Sci J. Supplement 2019;16(3) http://dx.doi.org/10.21123/bsj.2019.16.3(Suppl.).0740.
Weinstein T, Avry C, Asher K., Mona B, Yaacov O, Michal H, et al. Haemolysis in hemodialysis patients: evidence for impaired defense mechanisms against oxidative stress. Nephrol Dial transplant.2000;15:883-887.
Ko S, Chung HH, Cho SB, Jin YW, Kim KP, Ha M, et al. Occupational radiation exposure and its health effects on interventional medical workers: Study protocol for a prospective cohort study. Br Med J. Open. 2017;7(12).
Wolny-Rokicka E, Tukiendorf A, Wydmański J, Brzezniakiewicz-Janus K; Zembroń-Łacny A. The Effect of Radiotherapy on the Concentration of Plasma Lipids in Elderly Prostate Cancer Patients. Am J Mens Health. 2019 Mar 1;13(2).
Copyright (c) 2022 Baghdad Science Journal
This work is licensed under a Creative Commons Attribution 4.0 International License.