This is a preview and has not been published.

Synthesis, Characterization , Thermal Studies and Antioxidant Activities of Transition Metal Complexes with Azo Dye ligand


  • Amnah Mahdi Abdullah Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad, Iraq.
  • Abbas Ali Salih Al-Hamdani Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad, Iraq.



Antioxidant, Azo dye, Mass spectroscopy, 1-(2,4,6-Trihydroxy-phenyl)-ethanone , Thermal analysis


Diazotization reaction between 1-(2,4,6-Trihydroxy-phenyl)-ethanone and diazonium salts was carried out resulting in ligand 4-(3-Acetyl-2,4,6-trihydroxy-phenylazo)-N-(5-methyl-isoxazol-3-yl)-benzenesulfonamide, this in turn reacted with the next metal ions (V4+ , Cr3+ , Mn2+ and Cu2+) forming stable complexes with unique geometries such as (Octahedral for both Cr3+ , Mn2+ and Cu2+ ,squar pyramidal for V4+). The creation of such complexes was detected by employing spectroscopic means involving ultraviolet-visible which proved the obtained geometries, fourier transfer proved the formation of azo group and and the coordination with metal ion through it. Pyrolysis (TGA & DSC) studies proved the coordination of water residues with metal ions inside the coordination sphere as well as chlorine atoms. Moreover, element micro-analysis and AAS that gave corresponding outcome with theoretically counting outcome. (1H &13C-NMR) and magnetic quantifications can also indicate the formation of ligand-H3L and occurrence of coordination. The thermodynamic constants (∆H, ∆S and ∆G) were calculated. The DPPH radical scavenging method will be used to assess the antioxidant activities of the compounds the compounds showed antioxidant abilities to scavenge free radical.


Download data is not yet available.


Ibraheem IH, Mubder NS, Abdullah MM, Al-Neshmi H. Synthesis, characterization and bioactivity Study from azo –ligand derived frommethyl-2-amino benzoatewith some metal ions. Baghdad Sci J. 2023; 20(1): 114-120.‏

Al-Hamdani AAS, Al Zoubi W. New metal complexes of N3 tridentate ligand: Synthesis, spectral studies and biological activity. Spectrochim Acta- A: Mol Biomol Spectrosc. 2015; 137: 75-89.

Al Zoubi, W, Al‐Hamdani AAS, Ahmed SD, Ko YG. Synthesis, characterization, and biological activity of Schiff bases metal complexes. J Phys Org Chem. 2018; 31(2): e3752.

Nagasundaram N, Govindhan C, Sumitha S, Sedhu N, Raguvaran K, et al. Synthesis, characterization and biological evaluation of novel azo fused 2, 3-dihydro-1H-perimidine derivatives: In vitro antibacterial, antibiofilm, anti-quorum sensing, DFT, in silico ADME and Molecular docking studies. J Mol Struct. 2022; 1248: 131437.‏

Hamad SF, Ibraheem TK. Synthesis, Characterize and Antibacterial Evaluate of Some Novel Compounds Containing 1, 3, 4-thiadiazole. J Pharm Negat. 2022; ( 13)3 1119-1122.‏

Al Zoubi W, Al‐Hamdani AAS, Widiantara IP, Hamoodah RG, Ko YG . Theoretical studies and antibacterial activity for Schiff base complexes. J Phys Org Chem. 2017; 30 (12): e3707.

Turan N, Buldurun K. Synthesis, characterization and antioxidant activity of Schiff base and its metal complexes with Fe (II), Mn (II), Zn (II), and Ru (II) ions: Catalytic activity of ruthenium (II) complex. Eur J Chem.2018; 9(1): 22-29.‏

Mohammed H. Synthesis, Identification, and Biological Study for Some Complexes of Azo Dye Having Theophylline. Sci world j. 2021 Jul 22; 2021.

Ispir E, Ikiz M, Inan A, Sünbül AB, Tayhan SE, Bilgin S, et al. Synthesis, structural characterization, electrochemical, photoluminescence, antiproliferative and antioxidant properties of Co (II), Cu (II) and Zn (II) complexes bearing the azo-azomethine ligands. J Mol Struct. 2019 Apr 15; 1182: 63-71.

Al Zoubi W, Al‐Hamdani AAS, Ahmed SD, Ko YG . A new azo‐Schiff base: Synthesis, characterization, biological activity and theoretical studies of its complexes. Appl Organometal Chem. 2017; e3895.

Lashanizadegan M, Ashari HA, Sarkheil M, Anafcheh M, Jahangiry S. New Cu (II), Co (II) and Ni (II) azo-Schiff base complexes: Synthesis, characterization, catalytic oxidation of alkenes and DFT study. Polyhedron. 2021 May 15; 200: 115148.

Kyei SK, Akaranta O, Darko G. Synthesis, characterization and antimicrobial activity of peanut skin extract-azo-compounds. Sci Afr. 2020 Jul 1; 8: e00406.

Mahdy AR, Ali OA, Serag WM, Fayad E, Elshaarawy RF, Gad EM. Synthesis, characterization, and biological activity of Co (II) and Zn (II) complexes of imidazoles-based azo-functionalized Schiff bases. J Mol Struct. 2022 Jul 5; 1259: 132726.

Kyhoiesh HA, Al-Adilee KJ. Synthesis, spectral characterization, antimicrobial evaluation studies and cytotoxic activity of some transition metal complexes with tridentate (N, N, O) donor azo dye ligand. Results Phys. 2021 Jan 1; 3: 100245.

Mandour HS, Abouel-Enein SA, Morsi RM, Khorshed LA. Azo ligand as new corrosion inhibitor for copper metal: Spectral, thermal studies and electrical conductivity of its novel transition metal complexes. J Mol Struct. 2021 Feb 5; 1225: 129159.

Minnelli C, Laudadio E, Galeazzi R, Rusciano D, Armeni T, Stipa P, Mobbili G. Synthesis, characterization and antioxidant properties of a new lipophilic derivative of edaravone. Antioxidants. 2019; 8(8): 258.‏

Hamza IS, Mahmmoud WA, Al-Hamdani AA, Ahmed SD, Allaf AW, Al Zoubi W. Synthesis, characterization, and bioactivity of several metal complexes of(4-Amino-N-(5-methyl-isaxazol-3-yl)-benzenesulfonamide) . Inorg. Chem Commun. 2022; 144: 109776.

Unnisa A, Abouzied AS, Baratam A, Lakshmi KC, Hussain T, Kunduru RD, et al. Design, synthesis, characterization, computational study and in-vitro antioxidant and anti-inflammatory activities of few novel 6-aryl substituted pyrimidine azo dyes. Arab J Chem. 2020; 13(12): 8638-8649.‏

Keshavayya J, Pushpavathi I, Keerthikumar CT, Maliyappa MR, Ravi BN. Synthesis, characterization, computational and biological studies of nitrothiazole incorporated heterocyclic azo dyes. J Struct Chem. 2020; 31(4): 1317-1329.‏

Moamen SR, Altalhi T , Safyah BB, Ghaferah HA, Kehkashan A. New Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Zn(II), Cd(II),and Hg(II) Gibberellate Complexes: Synthesis, Structure,and Inhibitory Activity Against COVID-19 Protease. Russ J Gen Chem. 2021; 91(5): 890–896.

Reda SM, Al-Hamdani AAS. Mn (II), Fe (III), Co (II) and Rh (III) complexes with azo ligand: Synthesis, characterization, thermal analysis and bioactivity.Baghdad Sci J. 2022; 91(5):890-896.

Maliyappa MR, Keshavayya J, Mallikarjuna NM, Krishna PM, Shivakumara N, Sandeep T, et al. Synthesis, characterization, pharmacological and computational studies of 4, 5, 6, 7-tetrahydro-1, 3-benzothiazole incorporated azo dyes. J Mol Struct. 2019; 1179: 630-641.‏

Al-Daffay RK, Al-Hamdani AA. Synthesis, Characterization, and Thermal Analysis of a New Acidicazo Ligand's Metal Complexes. Baghdad Sci J. 2022; 19(3): 121-33. :

Turan N, Buldurun K. Synthesis, characterization and antioxidant activity of Schiff base and its metal complexes with Fe (II), Mn (II), Zn (II), and Ru (II) ions: Catalytic activity of ruthenium (II) complex. Eur J Chem. 2018 Mar 31; 9(1): 22-9.

EL-Gammal OA, Alshater H, El-Boraey HA. Schiff base metal complexes of 4-methyl-1H-indol-3-carbaldehyde derivative as a series of potential antioxidants and antimicrobial: Synthesis, spectroscopic characterization and 3D molecular modeling. J Mol Struct. 2019 Nov 5; 1195: 220-30.

Al Zoubi W, Al‐Hamdani AAS, Susan DA, Hassan MB, Al‐Luhaibi RSA, Dib A, Young GK. Synthesis, characterization, and antioxidant activities of imine compounds. J Phys Org Chem. 2019; 32(3): e3916.

Olesya S, Alexander P. Antimicrobial activity of mono-and polynuclear platinum and palladium complexes. Foods Raw Mater. 2020; 8(2): 298-311.‏

Rezaei-Seresht E, Salimi A, Mahdavi B. Synthesis, antioxidant and antibacterial activity of azo dye-stilbene hybrid compounds. Pigm Resin Tchnol. 2019; 48(1): 84-88.

Kareem MJ, Al-Hamdani AAS, Ko YG, Al Zoubi, W, Mohammed Saad G. Synthesis, characterization, and determination antioxidant activities for new Schiff base complexes derived from 2-(1H-indol-3-yl)-ethylamine and metal ion complexes. J Mol Struct. 2021; 1231: 129669.

Turan N, Buldurun K, Adiguzel R, Aras A, Turkan F, et al. Investigation of spectroscopic, thermal, and biological properties of Fe(II), Co(II), Zn(II), and Ru(II) complexes derived from azo dye ligand. J Mol Struct. 2021 Nov 31; 1244: 130989.

Al-Hamdani AAS, Al-Alwany TAM, Mseer MA, Fadhel AM, Al-Khafaji YF. Synthesis, Characterization, Spectroscopic, Thermal and Biological Studies for New Complexes with N1, N2-bis (3-hydroxyphenyl) Oxalamide. EgyptJ. of Chem. 2023 66(4): 223-235. 10.21608/EJCHEM.2022.144403.6297