Fat Mass and Obesity Association gene Polymorphism in PCOS Iraqi Women

Main Article Content

Qais Ahmed Ibraheem
https://orcid.org/0000-0002-2501-8835
Luma Hasan Alwan Al Obaidy
https://orcid.org/0000-0002-7649-4516
Gulboy Abdolmageed Nasir
https://orcid.org/0000-0003-4917-9972
Manal Taha Al Obaidi
https://orcid.org/0000-0001-8722-3159

Abstract

             Polycystic syndrome (PCOS) is a considerable infertility disorder in adolescents and adult women in reproductive age. Obesity is a vigorous risk factor related to POCS.  This study aims to evaluate the association of obesity and PCOS by investigating several parameters including:  anthropological, biochemical (lipid profile, fasting blood sugar, glucose tolerance test, and hormone levels (LH, FSH, LH/FSH ratio, Estradiol2 and Testosterone),and genetic parameters (Fat mass and Obesity associated gene (FTO) polymorphism at rs17817449) in 63 obese and non-obese PCOS women. The biochemical tests were investigated by colorimetric methods while FTO gene polymorphism was detected by PCR–RFLP.  Lipid profile, FBS, GTT, hormones (LH, LH/FSH ratio) in obese PCOS patients were significantly higher than non-obese non PCOS patients. It was found that the FTO variant TT risk genotype is a predisposing factor to obesity but not for PCOS. The study substantiated a possible familial risk factor for developing obesity among women in the same family.

Article Details

How to Cite
1.
Fat Mass and Obesity Association gene Polymorphism in PCOS Iraqi Women. Baghdad Sci.J [Internet]. 2020 Sep. 8 [cited 2024 Mar. 29];17(3(Suppl.):1103. Available from: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/4642
Section
article

How to Cite

1.
Fat Mass and Obesity Association gene Polymorphism in PCOS Iraqi Women. Baghdad Sci.J [Internet]. 2020 Sep. 8 [cited 2024 Mar. 29];17(3(Suppl.):1103. Available from: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/4642

Similar Articles

You may also start an advanced similarity search for this article.