Simultaneous Ratio Derivative Spectrophotometric Determination of Paracetamol, Caffeine and Ibuprofen in Their Ternary Form

Authors

  • Khalaf F. Alsamarrai Department of Chemistry, College of Education, University of Samarra, Samarra, Iraq https://orcid.org/0000-0001-7980-8640
  • Suham Tawfeq Ameen Department of Medical Laboratory Techiniques, College of Medical & Health Technology Uruk University, Baghdad, Iraq

DOI:

https://doi.org/10.21123/bsj.2022.6422

Keywords:

Caffeine, Ibuprofen, Paracetamol, Peak area, Ratio derivative

Abstract

A new, accurate, precise and economic two spectrophotometric methods for determination of Paracetamol (Par), Ibuprofen (Ibu), and Caffeine (Caf) were suggested. Those methods were the first and second ratio derivative spectrum using a double devisor. Par, Ibu, and Caf showed many useful peaks for their quantified determination. The validity of all analysis modes for determination of the three compounds, peak to baseline, peak area and peak to peak were according to ICH. The linearity of two methods was between 5 µg/ml as a lower concentration and 50 µg/ml as the highest concentration for three compounds. Recovery percentage was around 100% and relative standard deviation was less than 2.6%. The methods were applied successfully in the determination of Par, Ibu, and Caf in pure and pharmaceutical forms.

References

Kennedy AR, King NL, Oswald ID, Rollo DG, Spiteri R, Walls A. Structural study of salt forms of amides; paracetamol, benzamide and piperine. J Mol Struct. 2018 Feb 15; 1154: 196-203.

Saragiotto BT, Shaheed CA, Maher CG. Paracetamol for pain in adults. BRIT MED J 2019 Dec 31; 367.

Hejaz HA, Kanan A, Al Mohtaseb M, Ja’bari A. Development and characterization of paracetamol medicated lollipops. Pharm Technol Hosp Pharm. 2020 Jan 1;5(1).doi.10.1515/pthp-2020-0012

‏ Cunha RR, Chaves SC, Ribeiro MM, Torres LM, Muñoz RA, Dos Santos WT, et al Simultaneous determination of caffeine, paracetamol, and ibuprofen in pharmaceutical formulations by high-performance liquid chromatography with UV detection and by capillary electrophoresis with conductivity detection. J Sep Sci. 2015 May;38(10):1657-62. doi: 10.1002/jssc.201401387. Epub 2015 Apr 20. PMID: 25773878. ‏

Monteiro JP, Alves MG, Oliveira PF, Silva BM. Structure-bioactivity relationships of methylxanthines: Trying to make sense of all the promises and the drawbacks. Molecules. 2016 Aug; 21(8):974.

Dagan Y, Doljansky JT. Cognitive performance during sustained wakefulness: a low dose of caffeine is equally effective as modafinil in alleviating the nocturnal decline. Chronobiol Int. 2006 Jan 1; 23(5):973-83.

Cousins MJ, Brennan F, Carr DB. Pain relief: a universal human right. Pain 2004; 112(1-2): 1-4.

Merry A, Power I. Perioperative NSAIDs: towards greater safety. Pain Rev. 1995; 2: 268-91.

Saljoughian Manouchehr. Acetaminophen intoxication: a critical-care emergency. US Pharm, 2016; 41.12: 38-41.

Daniele C, Mazzanti G, Pittler MH, Ernst E. Adverse-Event Profile of Crataegus Spp. Drug saf. 2006 Jun; 29(6): 523-35.

Mehlisch DR. The efficacy of combination analgesic therapy in relieving dental pain. J Am Dent Assoc. 2002 Jul 1; 133(7):861-71.

Gazal G, Mackie IC. A comparison of paracetamol, ibuprofen or their combination for pain relief following extractions in children under general anaesthesia: a randomized controlled trial. Int J Paediatr Den. 2007 May; 17(3):169-77.

Raymond TJ, Tobin KA, Rogers TS. Nonopioid Pharmacologic Treatments for Chronic Pain. Am Fam Physician. 2021 May 1; 103(9): 561-5.

Mitchell A, van Zanten SV, Inglis K, Porter G. A randomized controlled trial comparing acetaminophen plus ibuprofen versus acetaminophen plus codeine plus caffeine after outpatient general surgery. J Am Coll Surg. 2008 Mar 1; 206(3):472-9.

Aktaş AH, Şahin HO. Spectrophotometric Determination of Paracetamol, Propyphenazone and Caffeine in Tablets by Multivariate Calibration Approach. Anal chem Indian j 2019;19(1):143.

Alkhafaji SL, Mahood AM. First-order Derivative and UV-spectrophotometric Methods for Simultaneous Determination of Paracetamol, Ibuprofen, and Caffeine in Bulk and Parmaceutical Formulatation. JPharm Res Int.. 2018:1-4.

Souri E, Nasab SA, Amanlou M, Tehrani MB. Development and validation of a rapid derivative spectrophotometric method for simultaneous determination of acetaminophen, ibuprofen and caffeine. J Anal Chem. 2015 Mar;70(3):333-8.

Muttiri S, Saraan D, Sinaga SM. Development method for the determination of ternary mixture of paracetamol, ibuprofen and caffeine in tablet dosage form using zero-crossing derivative spectrophotometric. Int J Pharm.Tech Res. 2015;7(2):349-53.

Dinç E, Kökdil G, Onur F. Derivative ratio spectra–zero crossing spectrophotometry and LC method applied to the quantitative determination of paracetamol, propyphenazone and caffeine in ternary mixtures. J Pharm Biomed Anal. 2001 Dec 1;26(5-6):769-78.

Okai CA, Orman E, Agyenim–Boateng A. Validation of Titrimetric-UV Spectrophotometric Method for the Simultaneous Quantification of Paracetamol, Caffeine and Ibuprofen in Pharmaceutical Dosage Forms. Br J Pharm Res.. 2016 Jul 31:1-4.

Thu NA. Quantification of acetaminophen, caffeine and ibuprofen in solid dosage forms by uv spectroscopy coupled with multivariate analysis. Asian J Pharm Anal. 2021 May 13;11(2):127-32.

Rathinam S, Santhana LK. Ecofriendly. Simple UV Spectrophotometric and Chemometric Methods for Simultaneous Estimation of Paracetamol Aceclofenac and Eperisone Hydrochloride in Pharmaceutical Formulation: Assessment of Greenness Profile. Processes, 2021 July 23; 9(8): 1272.‏

Kedar T R., Jadhav A. P, Kore K J, Jadhav R T. Development and validation of UV-Spectrophotometric methods for simultaneous estimation of Paracetamol and Ibuprofen in bulk and tablet dosage form.‏ Int J Res Trends Innov. 2020 May ;5(5):116-21. http://ijrti.org/papers/IJRTI2005019.pdf

Chabukswar AR, Thakur VG, Kandale PV, Sharma SN, Kuchekar BS, Sonawane VN. Development and Validation of UV-Spectrophotometric Method for the Simultaneous Determination of Paracetamol, Ibuprofen and Caffeine in Pharmaceutical Dosage Form. Asian J Res Chem. 2014 Dec 28;7(12):1019-22

Hajian, R, Afshari, N. The spectrophotometric multicomponent analysis of a ternary mixture of ibuprofen, caffeine and paracetamol by the combination of double divisor-ratio spectra derivative and H-point standard addition method. E J Chem. 2012; 9(3), 1153-1164

Ahmed RK, Muhammad SS, Khodaer EA. Spectrophotometric Determination of Paracetamol in bulk and Pharmaceutical Preparations. Baghdad Sci J. 2015;12(2):317-323.

Sinan R, Abed SS. Nitroso-R-salt as a sensitive spectrophotometric reagent for the determination of paracetamol in pharmaceutical preparations. Baghdad Sci J., 2009, 6.3:570-577.

Vu Dang H, Truong Thi Thu H, Dong Thi Ha L, Nguyen Mai H. RP-HPLC and UV spectrophotometric analysis of paracetamol, ibuprofen, and caffeine in solid pharmaceutical dosage forms by derivative, fourier, and wavelet transforms: a comparison study. J Anal Methods Chem. 2020 Feb 8;1-13.doi.:10.1155/2020/8107571

Palled PJ, Dushyanth RV, Mannor VS, Chowdary B. Validated isocratic/gradient RP-HPLC for simultaneous estimation of paracetamol, ibuprofen and caffeine in marketed formulations using diclofenac as internal standard. Anal Chem IndianJ. 2017;17(1):116.

Darkwah EK, Acquah CK, Lambon PS, Ameko DK, Akanji O, Ayim JS. Simultaneous Quantification of Acetaminophen, Caffeine, and Ibuprofen in Fixed Dose Combination Drug Using HPLC with UV Detection. J AdvMed Pharm Sci. 2019 Apr 20(2):1-9.

Pereira FJ, Rodríguez-Cordero A, López R, Robles LC, Aller AJ. Development and Validation of an RP-HPLC-PDA Method for Determination of Paracetamol, Caffeine and Tramadol Hydrochloride in Pharmaceutical Formulations. Pharmaceuticals [Internet]. MDPI AG; 2021 May 15;14(5):466.http://dx.doi.org/10.3390/ph14050466

Santos AM, Silva TA, Vicentini FC, Fatibello-Filho O. Flow injection analysis system with electrochemical detection for the simultaneous determination of nanomolar levels of acetaminophen and codeine. Arab J Chem. 2020 Jan 1;13(1):335-45.

Serrano i Plana N, Castilla Ō, Ariņo Blasco C, Díaz Cruz S, Díaz Cruz JM. Commercial screen-printed electrodes based on carbon nanomaterials for a fast and cost-effective voltammetric determination of paracetamol, ibuprofen and caffeine in water samples. Sens, 2019 Sep 19; 19(18). 4039.

Feyisa TY, Kitte SA, Yenealem D, Gebretsadik G. Simultaneous electrochemical determination of paracetamol and caffeine using activated glassy carbon electrode. Anal Bioanal Electrochem.. 2020 Jan; 12(1): 93-106.

Katseli V, Economou A, Kokkinos C. A novel all-3D-printed cell-on-a-chip device as a useful electroanalytical tool: Application to the simultaneous voltammetric determination of caffeine and paracetamol. Talanta. 2020 Feb 1; 208:120388.

Downloads

Published

2022-12-01

Issue

Section

article

How to Cite

1.
Simultaneous Ratio Derivative Spectrophotometric Determination of Paracetamol, Caffeine and Ibuprofen in Their Ternary Form. Baghdad Sci.J [Internet]. 2022 Dec. 1 [cited 2024 Mar. 28];19(6):1276. Available from: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/6422

Similar Articles

You may also start an advanced similarity search for this article.