Determination of Sulfacetamide Sodium in Pure and Their Pharmaceutical Formulations by Using Cloud Point Extraction Method

Main Article Content

Nisreen jassam Alaallah
Saadiyah Ahmad Dhahir
Hameed Hussein Ali

Abstract

      In this study, simple, low cost, precise and speed spectrophotometric methods development for evaluation of sulfacetamide sodium are described. The primary approach contains conversion of sulfacetamide sodium to diazonium salt followed by a reaction with p-cresol as a reagent in the alkaline media.  The colored product has an orange colour with absorbance at λmax 450 nm. At the concentration range of (5.0-100 µg.mL-1), the Beer̆ s Low is obeyed with correlation coefficient (R2= 0.9996), limit of detection as 0.2142 µg.mL-1, limit of quantification as 0.707 µg.mL-1 and molar absorptivity as 1488.249 L.mol-1.cm-1. The other approach, cloud point extraction was utilized to an estimation of a trace amount of the colored product in the previous procedure followed by a measuring process with a UV-Vis spectrophotometer. The linearity of the calibration graph was above the range of (1.0-60 µg.mL-1), the correlation coefficient (R2= 0.9991) and molar absorptivity was 7417.622 L.mol-1.cm-1. The detection limit(LOD) and quantification limit(LOQ) were based to be  0.070 and 0.231 µg.mL-1 , respectively. This approach was successfully employed for sulfacetamide sodium detection within the pure and pharmaceutical formulation.

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Determination of Sulfacetamide Sodium in Pure and Their Pharmaceutical Formulations by Using Cloud Point Extraction Method. Baghdad Sci.J [Internet]. 2021 Sep. 1 [cited 2024 Mar. 28];18(3):0575. Available from: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/5052
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How to Cite

1.
Determination of Sulfacetamide Sodium in Pure and Their Pharmaceutical Formulations by Using Cloud Point Extraction Method. Baghdad Sci.J [Internet]. 2021 Sep. 1 [cited 2024 Mar. 28];18(3):0575. Available from: https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/5052

References

Pharmacopoeia B, London. The Stationary Office on behalf of the Medicines and Healthcare products Regulatory Agency (MHRA), 2016.

Brunton L L ,Knollmann B C. As Bases Farmacológicas da Terapêutica de Goodman e Gilman-13, 2018 Artmed Editora.

Ahmed S, Anwar N, Sheraz M A, Ahmad I. Validation of a stability-indicating spectrometric method for the determination of sulfacetamide sodium in pure form and ophthalmic preparations. J. Pharm. Bioallied Sci. 2017; 9(2): 126.

Al-Uzri W A Fadil G. Spectrophotometric Determination of Sulfacetamide Sodium in Pharmaceutical Preparation Using 8-Hydroxy-7-iodoquinoline-5-sulfonic Acid as Chromogenic Reagent. Asian J. Chem. 2017;. 29(4): 782.

Errayess S A, Lahcen A A, Idriss L i, Marcoaldi C, Chiavarini S, Amine A. A sensitive method for the determination of Sulfonamides in seawater samples by Solid Phase Extraction and UV–Visible spectrophotometry.Spectrochim. Acta Part A Mol. Biomol. Spectrosc. 2017;181:. 276–285.

Darweesh S A , Al-Haidari I M A , Mohammed A K, Dikran S B . Spectrophotometric determinations of sulfacetamide following simple diazotization and coupling with chromotropic acid. Ibn AL-Haitham J. Pure Appl. Sci. 2017; 26(3): 281–295.

Injac R, Mlinaric A, Djorjevic-Milic V , Karljikovic-Rajic K Strukelj B. Optimal conditions for determination of zinc bacitracin, polymyxin B, oxytetracycline and sulfacetamide in animal feed by micellar electrokinetic capillary chromatography. Food Addit. Contam.2008; 25,( 4): 424–431.

Gallego J M L, Arroyo J P. Determination of prednisolone acetate, sulfacetamide and phenylefrine in local pharmaceutical preparations by micellar electrokinetic chromatography. J. Pharm. Biomed. Anal. 2003; 31( 5): 873–884.

Yadav S K , Choubey P K, Agrawal B,Goyal R N.Carbon nanotube embedded poly 1, 5-diaminonapthalene modified pyrolytic graphite sensor for the determination of sulfacetamide in pharmaceutical formulations . Talanta. 2014; 118:96–103.

Borras S, Companyo R, Guiteras J. Analysis of sulfonamides in animal feeds by liquid chromatography with fluorescence detection.J. Agric. Food Chem. 2011; 59(10) : 5240–5247.

Shaaban H , Górecki T .Optimization and validation of a fast ultrahigh pressure liquid chromatographic method for simultaneous determination of selected sulphonamides in water samples using a fully porous sub‐2 μm column at elevated temperature. J. Sep. Sci. 2012;35(2): 216–224.

El-Ragehy N A , Hegazy M A, AbdElHamid G and Tawfik S A .Validated Chromatographic Methods for the Simultaneous Determination of Sulfacetamide Sodium and Prednisolone Acetate in their Ophthalmic Suspension. J. Chromatogr. Sci. 2017;. 55 (10): 1000–1005 .

Issa Y M , El-Ansary A L, Selim W .Enthalpimetric determination of sulfa drugs in pure form and pharmaceutical formulations. Anal. Lett. 1998;. 31,(1): 131–146.

Ayad M R, Ali H M, Musa L A. Spectrophotometric determination of sulfacetamide in pure form and pharmaceutical formulations with metol and potassium hexacyanoferrate (ΙΙΙ). Al-Mustansiriyah J. Pharm. Sci. 2012 ; 12 ( 2): 189–199.

Bonta V , MARGHITAS L A, Dezmirean D, BOBIS O. Determination of six sulfonamide residues in honey by HPLC with fluorescence detection. Bull. Univ. Agric. Sci. Vet. Med. Cluj-Napoca. Anim. Sci. Biotechnol.,2009; 66: 1–2.

Dhahir S A. Determination of mercury and manganese by using new reagent azo after cloud point extraction for some environmental sample in Iraq. Am. J. Environ. Sci. 2015;11 ( 5): 392.

Bakir S R ,Dhahir A.Cloud Point Extraction spectrophotometric Determination of Trace Amounts of Nickel by SALEN as reagent in waste water of Iraq. Online Int Interdiscip Res J .2013 ; 3:9–21.

Dhahir S A, Kadhim E A , AL-Gani R H A .Micro Spectrophotometric Determination and Cloud Point Extraction of Sulphadimidine Sodium in Pure form and Pharmaceutical Drug.Baghdad Sci. J. 2019; 16,( 2): 332–344.

Dhahir S A , Mohammed N J. Cloud Point Extraction And Spectrophotometric Determination Of Cephalexin Drugs In Pharmaceuticals Preparation Through Complex Formation With Hg (II) And Ni (II). Res. J. Pharm. Biol. Chem. Sci. 2019; 10 (1) : 275–293.

Thani M Z , Al-Ameri S A H ,Sultan M S .Spectrophotometeric Determination of Ponceau 4R in the Several Beverages Using Mixed Micelles after Cloud Point Extraction. J. Al-Nahrain Univ. 2018;21(1): 8–13.

John E M. Organic chemistry. 8th Edition: 2012.

Nagaraja P, Shailendra D N, Ashwinee KS, Anantharaman S. A sensitive spectrophotometric method for the determination of sulfonamides in pharmaceutical preparations. Acta Pharm. 2007; 57 : 333–342

Wasan A A. Spectrophotometric Determination of Sulfacetamide Sodium in Pharmaceutical Preparation Using 8-Hydroxy-7-iodoquinoline-5-sulfonic Acid as Chromogenic Reagent. A J C. 2017; 29(4):782-786 .

Isam J A, Al-Obaydi I . Direct Determination of Sulfacetamide Sodium by Derivative UV SpectrophotometryJou. Raf. Sci. 2009; 20(4): 17-26.

Saad H S. Spectrophotometric Assay of Sulphacetamide Sodium in Ophthalmic Preparation Using 2,6-Dihydroxytoluene as a New Coupling Agent. Al-Rafidain Science Journal. 2019;28(3): 116-127.

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