Abstract
The present study aimed to evaluate sera TGF- β1 concentration in patients with urinary bladder carcinoma (UBC). All malignant of them was transitional cell carcinoma (TCC) type , patients with urinary bladder disorders (UBD ) and healthy control , and to study the correlation between sera TGF-β1 levels and tumor stages and grades in UBC patients . A direct ELISA test was used to quantify the seraTGF-β1 concentrations in sera of 58 patients with urinary bladder carcinoma UBC of different grades (G) and stages (T) all malignant of them was transitional cell carcinoma (TCC) type , 15 from patients with UBD and 15 healthy subjects . Sera levels of TGF-β1 were elevated in patients with UBC and UBD compared to healthy (P ≤ 0.01) .There was no association between tumor stages and serum level of TGF-β1 (P˃0.05) . Whereas there was an association between serum levels of TFG-β1 and tumor grades (p ≤0.05) . Increased serum level was found in high grades G≥2 of patient with UBC .
Keywords
Urinary bladder carcinoma, TGF-β1
Article Type
Article
How to Cite this Article
Mousa, Hind M.; Jassem, Amna N.; and Hussain, Munther J.
(2014)
"Role of TGF-β1 in Urinary Bladder Carcinoma,"
Baghdad Science Journal: Vol. 11:
Iss.
4, Article 9.
DOI: https://doi.org/10.21123/bsj.2014.11.4.1481-1485
