Abstract
New series of Schiff bases 2(a-j) and corresponding beta-lactam derivatives 3(a-j) were synthesized from cefalexin (1) as starting material. The compound (1) was reacted with different aldehydes and ketones to give Schiff bases derivatives 2(a-j). The synthesized Schiff bases were cyclized by chloroacetyl chloride in the presence of triethylamine to form beta-lactam derivatives 3(a-j). The compounds were characterized by deremination melting point, FT-IR and 1H NMR. The beta-lactam derivatives were screened in vitro antibacterial against some bacterial species
Keywords
cefalexin, Schiff base, Beta-lactam, Antibacterial activity
Article Type
Article
How to Cite this Article
AL-Tamimi, Entesar O.; Muslih, Raad M.; and Thejeel, Khalida A
(2015)
"Synthesis, Characterization and Antibacterial Activity of Cefalexin Dervatives,"
Baghdad Science Journal: Vol. 12:
Iss.
3, Article 14.
DOI: https://doi.org/10.21123/bsj.2015.12.3.546-554
