Synthesis and Characterization of Some New Azo Dyes Derivatives Via Chalcone and Study Some of Their Biological Activity

Authors

Hilal Masoud Abdullah, Department of Chemistry, College of Education for Pure Sciences Ibn Al-Haithem,University of Baghdad, IRAQ
Maysoon Tariq Tawfiq, Department of Chemistry, College of Education for Pure Sciences Ibn Al-Haithem,University of Baghdad, IRAQ

Abstract

This work includes synthesis of new six membered heterocyclic rings with effective amino group using the reaction of benzylideneacetophenone (chalcone) (1) with thiourea or urea in alcoholic basic medium to form: 1,3-thiazen-2-amine (2), and 1,3-oxazin-2-amine (8) respectively. The diazotization reaction was carried out with sodium nitrite in presence of hydrochloric acid to form diazonium salts which suffered coupling reaction with naphthols and phenols in the presence of sodium hydroxide to form colored azo dyes (4-7, and 10-13). o-methylation reaction of compounds (7) and (10) yielded : 1,3-thiazin -2-yl-diazenyl (14), and 1,3-oxazin-2-yl-diazenyl (15) respectively.The new compounds were characterized using various physical techniques like: UV-Vis., FT-IR, and 1HNMR spectra. Some new compounds were tested against bacteria.

Keywords

Heterocyclic, Azo dyes, Benzylideneacetophenone, Thiazine, Oxazine

Article Type

Article

How to Cite this Article

Abdullah, Hilal Masoud and Tawfiq, Maysoon Tariq (2016) "Synthesis and Characterization of Some New Azo Dyes Derivatives Via Chalcone and Study Some of Their Biological Activity," Baghdad Science Journal: Vol. 13: Iss. 1, Article 16.
DOI: https://doi.org/10.21123/bsj.2016.13.1.0122