Synthesis of New Some Imidazole Derivatives Containing β-Lactam Ring

Authors

Firyal Waly Askar, Department of Chemistry, College of Science, University of Al-Mustansirya
Rana Abid Ali, Department of Chemistry, College of Science, University of Baghdad
Thanaa Mahdi Al-Mouamin, Department of Chemistry, College of Science, University of BaghdadFollow

Abstract

In this work 5-methylene-yl - (2-methy –oxazole-4-one) (1H) imidazole (1) were synthesized from the reaction of L-Histidine with acetic anhydride and which converted to the of 5-methylene-yl-(2-methyl 3-amino imidazole-4-one)-1H-imidazole (2) by reaction with hydrazine hydrate. Schiff bases (3-6) were synthesized from the reaction of compound (2) with different aromatic aldehyde. Reaction of compounds (3-6) with chloroacetyl chloride gives azetidinone one derivatives (7-10). These compounds were characterized by FT-IR and some of them with 1H-NMR and 13C-NMR spectroscopy.

Keywords

L-Histidine, Schiff base, Imidzole.

Article Type

Supplemental Issue

How to Cite this Article

Askar, Firyal Waly; Ali, Rana Abid; and Al-Mouamin, Thanaa Mahdi (2016) "Synthesis of New Some Imidazole Derivatives Containing β-Lactam Ring," Baghdad Science Journal: Vol. 13: Iss. 2, Article 57.
DOI: https://doi.org/10.21123/bsj.2016.13.2.2NCC.0307