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Abstract

This study is carried out on patients with type 2 diabetes mellitus to assess the lipid profile, malondialdehyde, and glutathione. Our study is concerned with 51 (Iraqi Arab females) patients of type 2 diabetes mellitus compared with 31 control subjects unified in age, sex, and ethnic background. Lipid profile is measured by using commercially available kits, while the serum MDA and glutathione levels are measured by means of sandwich ELISA test using commercially available kits. Serum MDA is significantly higher (P<0.001) while glutathione is significantly lower (P<0.001) in type 2 diabetic patients when compared to the control. The normal levels of MDA (3.82 ± 0.77 nmol/ml) and GSH (2.23 ± 0.54 μg/ml) recorded for the non-diabetic females are significantly (p<0.001) increased and depleted in the diabetic patients who record (6.78 ± 1.21 nmol/ml) and (1.29 ± 0.23 μg/ml) for MDA, GSH respectively. Parameters of lipid profile were significantly increased (P<0.001), while HDL cholesterol significantly decreased (P<0.001) in patients compared to the control group. The receiver operator curve (ROC) analysis of the forthcoming variations revealed the descending order of serum MDA (0.999), GSH (0.984), HDL (0.817), LDL (0.796), T.C (0.974), TG (0.727) & serum VLDL (0.722) showing a significant variation. In conclusion, the study shows low levels of GSH and high levels of MDA in diabetic patients indicating increased oxidative stress, which is considered the main cause of type 2 diabetes mellitus, especially in obese individuals.

Keywords

Malondialdehyde, Glutathione, Lipid Profile, Diabetes Mellitus

Article Type

Supplemental Issue

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