Abstract
The oxidative stress is the result of an imbalance between oxidants and antioxidants in the body. Hypertension (HT) is a measure of average systolic blood pressure, which is created by the heart contracting, greater than or equal to 140 mmHg, or an average diastolic blood pressure, which is the heart filling, of ≥ 90 mmHg. The study is conducted on 28 female patients with HT from Ibn Al-Nafese hospital in addition to 28 female controls. The markers measured are albumin, malondialdehyde (MDA), and 8-Hydroxy deoxyguanosine (8-OHdG). An electrophoresis study on extracted DNA with the Fenton reaction was also done. Results of this study show there is a highly significant decrease (p≤0.01) in albumin concentration of patients compared to the control, and there is a highly significant increase (p≤ 0.01) in each MDA and 8-OHdG for the patient group in comparison with controls. The Fenton reaction shows that the oxidant has a degradation effect on DNA even in two minutes of reaction. It is concluded that oxidative stress in its parameters (albumin) and markers (MDA and 8-OHdG) is the main chemical manifestation in the group under study. Oxidants produced by Fenton can denature the DNA in vitro.
Keywords
Hypertension, Reactive oxygen species Malondialdehyde, 8-OHdG
Article Type
Supplemental Issue
How to Cite this Article
Aldeen, Yasmeen Muhi; Habeeb, Perry; and Jawad, Alaa H.
(2016)
"Study Oxidative Stress Statues In Hypertension Women,"
Baghdad Science Journal: Vol. 13:
Iss.
2, Article 67.
DOI: https://doi.org/10.21123/bsj.2016.13.2.2NCC.0407
