Abstract
We propose two simple, rapid, and convenient spectrophotometric methods for the determination of cephalexin in bulk and pharmaceutical preparations. The first method is based on the measurement of the flame atomic emission of potassium ion, and the second method involves the colorimetric determination of the green-colored solution formed after the reaction of cephalexin with potassium permanganate as an oxidant agent in basic medium, measured at 610 nm. The working conditions of the methods are investigated and optimized. Beer's law plot shows a good correlation in the concentration range of 5-40 μg/ml. The detection limits are 2.573, 2.814 μg/ml for the flame emission photometric method and 1.844, 2.016 μg/ml for the colorimetric method for capsules and suspensions respectively. The methods are successfully applied to the determination of cephalexin in capsules and suspensions, and the obtained results are in good agreement with the label claim. No interference is observed from commonly encountered additives and excipients.
Keywords
Cephalexin, FlameAtomic Emission, Colorimetry
Article Type
Supplemental Issue
How to Cite this Article
Al-kahdimy, Abbas S. Hasan and Ahmed, Mohammed Abdullah
(2016)
"Flame Atomic Emission and Colorimetric Methods for the Determination of Cephalexin Monohydrate in Pharmaceutical Preparations,"
Baghdad Science Journal: Vol. 13:
Iss.
2, Article 74.
DOI: https://doi.org/10.21123/bsj.2016.13.2.2NCC.0480
