Abstract
In this paper some chalcones (C1-C8) are prepared based on the reaction of one mole of substituted acetophenone with one mole of substituted benzaldehydes in the presence of (40%) sodium hydroxide as a base. Pyrazolines (P1–P8) are prepared from the reaction of chalcones (C1-C8) with hydrazine hydrate. Isoxazoline (I1-I8) is prepared from the reaction of chalcones (C1-C8) with hydroxyl amine hydrochloride in the presence of (10%) sodium hydroxide as a base. These compounds are characterized by using various physical and spectral methods. The compounds are screened for their in vitro antibacterial activity using gram-positive bacteria and gram-negative bacteria. Several derivatives of pyrazolines and isoxazolines are produced well to moderate activities against number of bacteria.
Keywords
Chalcones, Pyrazolines, Isoxazolines, Antibacterial
Article Type
Article
How to Cite this Article
Al-Naseeri, Ali K. Alywee
(2016)
"Synthesis and Characterization of Some New Pyrazoline and Isoxazoline Derivatives as Antibacterial Agents,"
Baghdad Science Journal: Vol. 13:
Iss.
3, Article 17.
DOI: https://doi.org/10.21123/bsj.2016.13.3.0568
