Synthesis and study of biological activity of some new Imidazole derivatives

Authors

Abdul Jabar Kh. Atia, Department of Chemistry, College of Science, Al-Mustansiriya University
Mohammed fraj Al-Marjani, Department of Biology, College of Science, Al-Mustansiriya University
Muayad Abbood Qaban, Department of Chemistry, College of Science, Al-Mustansiriya University

Abstract

In this work ester derivatives were synthesized by the reaction of imidazole derivatives (C1) with ethylchloroacetate in ethanol and NaOH to give the corresponding (C2) .While compound (C3) acetohydrazide was synthesized by the reaction of ester derivatives (C2) with hydrazine hydrat in ethanol. Compound (C3) from the reaction with different aromatic aldehydes in absolute ethanol gave the Schiff′s bases (C4,C5). The product compounds were characterized by FT-IR, U.V and 1HNMR spectra and the biological activities were studied as antibacterial.

Keywords

acetohydrazide, Schiff′s bases, Imidazole

Article Type

Article

How to Cite this Article

Atia, Abdul Jabar Kh.; Al-Marjani, Mohammed fraj; and Qaban, Muayad Abbood (2016) "Synthesis and study of biological activity of some new Imidazole derivatives," Baghdad Science Journal: Vol. 13: Iss. 3, Article 25.
DOI: https://doi.org/10.21123/bsj.2016.13.3.0547