Spectrophotometric determination of Metronidazole and Metronidazole benzoate via first and Second Derivative order spectroscopy

Authors

Assist. Lecturer Hussein Abdul jabbar Alsamarrai
Assist. Prof. Khalaf F. Alsamarrai

Abstract

A New Spectrophotometric Methods are improved for determination Metronidazole (MTZ) and Metronidazolebenzoate (MTZB) depending on1STand 2nd derivative spectrum of the two drugs by using ethanol as a solvent. Many techniques were proportionated with concentration (peak high to base line, peak to peak and peak area). The linearity of the methodsranged between(1-25µg.ml-1) is obtained. The results were precise and accurate throw RSD% were between (0.041-0.751%) and (0.0331-0.452%), Rec% values between (97.78, 101.87%) and (98.033-102.39%) while the LOD between (0.051-0.231 µg.ml-1) and (0.074-1.04 µg.ml-1) and LOQ between (0.170-0.770µg.ml-1) and (0.074-0.313 µg.ml-1) of (MTZ) and of (MTZB) respectively. These Methods were successfully applied to determination of (MTZ) and (MTZB) in the pharmaceutical preparatio; ns

Keywords

Spectrophotometric, determination, Metronidazole and Metronidazole Benzoate, First and second order derivative of spectrum

Article Type

Article

How to Cite this Article

Alsamarrai, Assist. Lecturer Hussein Abdul jabbar and Alsamarrai, Assist. Prof. Khalaf F. (2017) "Spectrophotometric determination of Metronidazole and Metronidazole benzoate via first and Second Derivative order spectroscopy," Baghdad Science Journal: Vol. 14: Iss. 2, Article 11.
DOI: https://doi.org/10.21123/bsj.2017.14.2.0320