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Abstract

Cancer stay to be oneofthe leading causes of death throughout the worlddue to a limited success to usetreatments. The new synthesized metal complexes with formula: [Ni L2(H2O)2]. 2.5 E t OH and [Cd L2]. ½ H2O Where L = Bis [ 5 –( P –nitrophenyl ) -4 –phenyl 1 , 2 , 4 –trazol –3 –dithiocarbamato hydrazide ] and the aqueous extract of TeucriumpoliumL.(TP)plant (Ja,adahin Arabic) were examined against growth cells of hepatocellular Carcinoma cell Line ( HeP2 ).The cytotoxicity assayof cancer cell linewasused for determination of inhibition rate with three concentrations;(62.5, 105 and 250 μg /200μl). The aqueous extract of TPplant induced death of cancer cells by significant elevation of the inhibition rate to 50.03% while the cytotoxic effect of Ni ( II ) complex reached 45.77% and Cadmium (II) was 35.73% at 125μg /200μl.The present study indicates that there are no significant differences between the two new complexes Nickel(II) and Cadmium(II) compared with anticancer drug Cis-pt for all doses

Keywords

Nickel(II) complexes, Cadmium (II) Complexes, Cancer cell line

Article Type

Article

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