Abstract
This research includes astudy of Methylenetetrahydrofolate reductase gene’s allele 677C→T and its correlation with oxidative stress and their impact on female infertility. Fifty infertile womenwiththe range age (23-42) years and twenty five fertile womenwiththe range age (22-39)years as control group living in Erbil city were selected. The serum level of Malondialdehyde (MDA), superoxide dismutase (SOD), prolactinhormone(PRL), Luteinizing hormone (LH), Thyroid stimulating hormone (TSH), Triiodothyronine hormone (T3), and Thyroxine hormone (T4) were measured, also a body mass index(BMI) was calculated. A restriction enzyme (Hinf1) was used to improve the mutation in DNA bands of infertile women. The results showed significant increasesin MDA level, SOD activity, BMI, PRL, LH, TSH, and T4in patients womencomparedwiththecontrol group.Theresults show non-significant differences in T3 hormone levels. The results also show a mutation in DNA bands of infertile women compared with fertile control group.
Keywords
Female infertility (FI), Methylenetetrahydrofolate reductase (MTHFR) gene, Oxidative stress (OS).
Article Type
Article
How to Cite this Article
Thabit, Muthanna A.; Abdullah, Gaylany H.; and AL-Rawi, Khalid F.
(2017)
"Polymorphism study of MTHFR 677C→T and its correlation with oxidative stress and their influence on female infertilityin Erbil –Iraq,"
Baghdad Science Journal: Vol. 14:
Iss.
3, Article 19.
DOI: https://doi.org/10.21123/bsj.2017.14.3.0611
