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Abstract

Determination of the level of adipokines (obestatin, vaspin, tumor necrosis factor-α and interleukin-6)in hypo-and hyperthyroid patients from Educational Baghdad Hospital in Baghdad City was investigated. Fifty patients with hypothyroidism and Fifty patients with hyperthyroidism were selected. A control group of thirty euthyroid persons was included. Blood was collected by vein puncture and serum was separated and stored at –20C. Adipokines (obestatin,vaspin, tumor necrosis factor-αand interleukin-6) were estimated using ELISA method.The findings show a significant (p<0.05) increase in obestatin level in hypothyroid patients, while there isno significant difference in hyperthyroid patientsascompared with the euthyroid subjects. In addition, this study demonstrated a significant (p<0.05) increase in vaspin means in hypothyroid patients compared with euthyroid group. In hyperthyroid patients, there isa significant (p<0.05) decrease in vaspin level in comparison with euthyroid subjects.Furthermore, there isa significant (p<0.05) increase in tumor necrosis factor-α level in hypothyroid and hyperthyroid patients as compared with the euthyroid subjects. The results of this study also explain a significant (p<0.05) increase in interleukin-6 level in hyperthyroid patients, while there isnon-significant difference in hypothyroid patients compared with the euthyroid subjects. It is concludedfrom this studythat the levels of interleukin-6 and tumor necrosis factor-α increased in hyperthyroidism and decreased in hypothyroidism. Obestatin and vaspin were increased significantly in hypothyroid patients.

Keywords

Obestatin, vaspin, tumor necrosis factor-α, interleukin-6, hyperthyroid.

Article Type

Article

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