Abstract
Levan is an exopolysaccharide produced by various microorganisms and has a variety of applications. In this research, the aim was to demonstrate the biological activity of levan which produced from B. phenoliresistens KX139300. These were done via study the antioxidant, anti-inflammatory, anticancer and antileishmanial activities in vitro. The antioxidant levan was shown 80.9% activity at 1250 µg/mL concentration. The efficient anti-inflammatory activity of 88% protein inhibition was noticed with levan concentration at 35 µg/mL. The cytotoxic activity of levan at 2500 µg/mL concentration showed a maximum cytotoxic effect on L20B cell line and promastigotes of Leishmani tropica. Levan has dose-dependent anticancer and antileishmanial activities. An addition to the antioxidant, anti-inflammatory and anticancer potential activities of levan, it can be concluded that levan produced from B. phenoliresistens can efficiently be applied as an antileishmanial agent.
Keywords
Anticancer; Anti-inflammatory; Antioxidant; Antileishmanial; Brachybacterium phenoliresistens; Levan.
Article Type
Article
How to Cite this Article
Al-Halbosiy, Mohammad M.F.; Thabit, Zaid A.; Al-Qaysi, Safaa Al-Deen A. S; and Moussa, Tarek A.A.
(2018)
"Biological Activity of Levan Produced from Rhizospheric Soil Bacterium Brachybacterium phenoliresistens KX139300,"
Baghdad Science Journal: Vol. 15:
Iss.
3, Article 1.
DOI: https://doi.org/10.21123/bsj.2018.15.3.0238
