Abstract
Allopurinol derivative were prepared by reacting the (1-chloroacetyl)-2-Hydropyrazolo{3,4-d}pyrimidine-4-oneiwith 5- methoxy- 2-aminoibenzothiazoleiunder certain conditions to obtain new compound ( N- (2-aminoacetyl (5-methoxy) benzothiazole -2yl) (A4), Reaction of 5-(P-dimethyl amine benzene)-2-amino-1,3,4- oxadiazole in the presence of potassium carbonate anhydrous to yield new compound (N-(2- aminoacetyl-5-(P-dimethyl amine benzene )-1,3,4-oxadiazoles-2-yl)(A30) and Azo compound (N-(5-(Azo-2-hydroxy-5-amino benzene)-1,3-Diazol-2yl)Allopurinol(A46). The structure of prepared compounds were confirmed by (FT-IR) technique and their physical properties. The synthesized compounds were tested for cytotoxicity, Xanthine oxidase inhibition, and antioxidant activity.
Keywords
Allopurinol, Antioxidant Activity, Azo compound, Cytotoxicity, Xanthine Oxidase.
Article Type
Supplemental Issue
How to Cite this Article
J. Khammas, Sameaa and J. Hamood, Ahlam
(2019)
"Synthesis, Cytotoxicity, Xanthine Oxidase Inhibition, Antioxidant of New Pyrazolo{3,4 d}Pyrimidine Derivatives,"
Baghdad Science Journal: Vol. 16:
Iss.
4, Article 25.
DOI: https://doi.org/10.21123/bsj.2019.16.4(Suppl.).1003
