Abstract
This--study-was designed to examine association-between-174G/C-polymorphism of interleukin-6 gene and phosphate, calcium, vitamin D3, and parathyroid hormone levels in Iraqi patient with chronic kidney disease on maintenance hemodialysis. Seventy patients with -chronic renal-disease-(patients-group) and-20 healthy-subjects (control-group) were enrolled and genotyped for interleukin-6 polymorphism byconventional-polymerase-chain-reaction-restriction-fragment-length-polymorphism.There were nosignificant -differences-in phosphate -levels-observed-in –both patient-and -control-groups with -different interleukin-6 -genotypes. Control had non-significant differences in calcium levels, -while--patients--with-GG-and-GC-genotypes showed-significant elevation with time. Conversely, control and patients with GG and CC genotypes had significant elevation in vitamin D3levels with time.Regarding parathyroid hormone, control had non-significant differences,while patients with GG and CC genotypes showed significant elevation with time.A significant association was found between CKD patients with GG genotype and serum levels of calcium, vitamin D3and parathyroid hormone.
Keywords
CKD-MBD, Genetic polymorphism, Hemodialysis, Interleukin-6.
Article Type
Article
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
How to Cite this Article
Al-Radeef, Mohanad Yasir
(2020)
"Association between Allelic Variations of -174G/C Polymorphism of Interleukin-6 Gene and Chronic Kidney Disease-Mineral and Bone Disorder in Iraqi Patients,"
Baghdad Science Journal: Vol. 17:
Iss.
4, Article 2.
DOI: https://doi.org/10.21123/bsj.2020.17.4.1145
