Spectrophotometric and Spectrofluorimetric Determination of Terazosin in Tablets by Eosin Y

Authors

Zeena Z. Al abdali, Chemistry department, College of Education for Pure Sciences, Mosul University, Mosul, Iraq.Follow
Maysam H. Al Fakri, Chemistry department, College of Education for Pure Sciences, Mosul University, Mosul, Iraq.Follow

Abstract

Simple, sensitive and accurate two methods were described for the determination of terazosin. The spectrophotometric method (A) is based on measuring the spectral absorption of the ion-pair complex formed between terazosin with eosin Y in the acetate buffer medium pH 3 at 545 nm. Method (B) is based on the quantitative quenching effect of terazosin on the native fluorescence of Eosin Y at the pH 3. The quenching of the fluorescence of Eosin Y was measured at 556 nm after excitation at 345 nm. The two methods obeyed Beer’s law over the concentration ranges of 0.1-8 and 0.05-7 µg/mL for method A and B respectively. Both methods succeeded in the determination of terazosin in its tablets

Keywords

EosinY dye, Ion-pair complex, Spectrofluorimetric, Spectrophotometric method, Terazosin

Article Type

Supplemental Issue

How to Cite this Article

Al abdali, Zeena Z. and Al Fakri, Maysam H. (2021) "Spectrophotometric and Spectrofluorimetric Determination of Terazosin in Tablets by Eosin Y," Baghdad Science Journal: Vol. 18: Iss. 1, Article 40.
DOI: https://doi.org/10.21123/bsj.2021.18.1(Suppl.).0775