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Abstract

A sensitivity-turbidimetric method at (0-180o) was used for detn. of mebeverine in drugs by two solar cell and six source with C.F.I.A.. The method was based on the formation of ion pair for the pinkish banana color precipitate by the reaction of Mebeverine hydrochloridewith Phosphotungstic acid. Turbidity was measured via the reflection of incident light that collides on the surface particles of precipitated at 0-180o. All variables were optimized. The linearity ranged of Mebeverine hydrochloridewas 0.05-12.5mmol.L-1, the L.D. (S/N= 3)(3SB) was 521.92 ng/sample depending on dilution for the minimum concentration , with correlation coefficient r = 0.9966while wasR.S.D% < 1% of 2,6 mmol.L-1conc. of Mebeverine hydrochloride.The method is usedsuccessfully for three different of target drugs in three different pharmaceutical formulations. A comparison using t-test was studied. It was shown that there is no significant difference between two values..

Keywords

Mebeverine hydrochloride, Turbidity Flow injection analysis

Article Type

Article

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