Biogenic Functionalized ZnO/CuO Nanocomposite Sensor for Potentiometric Determination of Pseudoephedrine-HCl in Pure and Commercial Products

Authors

Fadam M. Abdoon, Department of Chemistry, College of Science, Tikrit University, Tikrit, IraqFollow
Sarhan A. Salman, Department of Chemistry, College of Science, Tikrit University, Tikrit, Iraq.Follow
Hasan M. Hasan, College of Pharmacy, Tikrit University, Tikrit, IraqFollow
Suham T. Ameen, College of Health and Medical Technology, Uruk University, Baghdad, IraqFollow
Maha F. El-Tohamy, Department of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi ArabiaFollow

Abstract

The ultrafunctional potential of zinc oxide (ZnO) and copper oxide (CuO) nanoparticles (NPs) has generated a great interest in using such metal oxides as remarkable and electroactive nanocomposites in the studies on potentiometry and sensors. These nano-oxides were prepared from the extract of Leucaena leucocephala seeds as an environmentally friendly process. The development of a ZnO/CuO “core-shell nanocomposite-modified” coated copper wire film sensor was proposed as a new method for potentiometric determination of pseudoephedrine hydrochloride (PSD) in pure and pharmaceutical dosage forms. With the existence of polyvinyl chloride (PVC) as a polymer with high molecular weight and “o-nitrophenyl octyl ether (o-NPOE) as a solvent mediator”, PSD was combined with phosphotungstic acid (PTA) to produce pseudoephedrine hydrochloride-phosphotungstate (PSD-PT) as a sensing substance. The improved sensor showed a very high sensitivity and selectivity for determining and quantifying the PSD with a linear relationship of 1.0×10-8-1.0×10-2 mol L-1. It was estimated that the regression equation was represented by the EmV = (-58.143) log [PSD] + 526.71. With the proposed sensors, pseudoephedrine hydrochloride could be effectively determined in pure and commercial product forms.

Keywords

Green Chemistry, Leucaena leucocephala, Polymeric Sensor, Pseudoephedrine HCl, ZnO/CuO nanocomposite

Article Type

Article

How to Cite this Article

Abdoon, Fadam M.; Salman, Sarhan A.; Hasan, Hasan M.; Ameen, Suham T.; and El-Tohamy, Maha F. (2024) "Biogenic Functionalized ZnO/CuO Nanocomposite Sensor for Potentiometric Determination of Pseudoephedrine-HCl in Pure and Commercial Products," Baghdad Science Journal: Vol. 21: Iss. 10, Article 18.
DOI: https://doi.org/10.21123/bsj.2024.9313