Synthesis, Spectral Characterization, Cytotoxic Assay, and Antimicrobial Evaluation Studies of Some Transition Metal Complexes of Schiff Base Derived From Amoxicillin

Authors

Alya’a J. Ahmed, Ministry of Higher Education and Scientific Research, Baghdad, IraqFollow
Amaal S. Sadiq, Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad, IraqFollow
Enaam Fadil Mousa, Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad, IraqFollow
Mahasin Alias, Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad, IraqFollow

Abstract

Four metal complexes of Schiff base ligand were prepared. To characterize both the ligand and the metal complexes, various techniques were employed, including elemental analysis, FT-IR spectroscopy, UV-Vis spectroscopy, molar conductivity measurements, magnetic moment determination, melting point, mass spectroscopy, ¹H-NMR and ¹³C-NMR spectroscopy. The results showed that the metal complexes formed have the formula [M(L)₂Cl₂]Cl_(n).H₂O, where L= Schiff base ligand and M=Cr(III), Rh(III), Pt(IV) and Au(III), n = 1, 2. Based on spectroscopic analysis, coordination with metal ions involves the ’N’ donor atom of N atoms of the imine and the N-H amid group, and four complexes are suggested to have a six-coordinated octahedral structure. Molar conductivity of these complexes showed that they were electrolytic in nature. In this study, the anticancer of the ligand and its metal complexes were investigated against MDA-MB-231 cell lines. Moreover, the in vitro efficacy them against Gram-negative bacteria (E. coli) and Gram-positive bacteria (S. aureus), as well as the fungal strain Candida albicans, was evaluated using the disc diffusion method. The results indicated that the complexes demonstrated the highest levels of cytotoxicity against MDA-MB-231 cell lines and antimicrobial activity more than the free ligand. These findings suggest that these metal complexes may have promising applications in the development of novel anticancer, antioxidant and antimicrobial agents.

Keywords

Antimicrobial, Amoxicillin, Cell lines, Metal complexes, Schiff base

Subject Area

Chemistry

Article Type

Article

First Page

3310

Last Page

3323

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite this Article

Ahmed, Alya’a J.; Sadiq, Amaal S.; Mousa, Enaam Fadil; and Alias, Mahasin (2025) "Synthesis, Spectral Characterization, Cytotoxic Assay, and Antimicrobial Evaluation Studies of Some Transition Metal Complexes of Schiff Base Derived From Amoxicillin," Baghdad Science Journal: Vol. 22: Iss. 10, Article 10.
DOI: https://doi.org/10.21123/2411-7986.5082