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Abstract

In the current study, ZrO2 nanoparticles were synthesized using a plant extract derived from Vitex agnus castus, and an alkaline medium such as sodium hydroxide. A biosynthetic approach was utilized to prepare zirconium oxide nanoparticles for this research project. This method stands out from others due to its cost-effectiveness, simplicity, and lack of potential risks.The prepared samples were characterized using transmission electron microscopy TEM, scanning electron microscopy SEM, Fourier transform infrared spectroscopy FT-IR, ultraviolet-visible spectroscopy UV-VIS, X-ray diffraction, and energy-dispersive X-ray spectroscopy EDX. The size of the crystal was determined using X-ray diffraction in conjunction with the Debye-Scherer equation, resulting in a value of 26.37 nm. Scanning electron microscopy and transmission electron microscopy were employed to ascertain the particle size of ZrO2 nanoparticles.In this study, these nanoparticles exhibited varying levels of activity against two types of gram-positive bacteria (Staphylococcus aurous and Streptococcus pneumonia), two types of gram-negative bacteria (Proteus mirabilis and Escharia coli), and one type of fungus, Candida. Interestingly, synthesized zirconium oxide nanoparticles' anticancer potential has been uncovered with MTT assays at varied concentrations for cell line A549 lung cancer. The percentage of inhibition revealed an increase with increasing concentration. Calculating the inhibition of half of the cells IC50, which was equal to (58.4 mg/ml), suggests that zirconium oxide nanoparticles have the potential for utilization in cancer treatment.

Keywords

Antibacterial, Biosynthesis approach, Cell line A549, Nanoparticles, Zirconium oxide

Subject Area

Mathematics

Article Type

Article

First Page

771

Last Page

780

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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