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Abstract

In the present investigation, the simultaneous determination of lisinopril and amlodipine in their pure forms and in pharmaceutical formulations were determined using third derivative spectrophotometry. The process is easy, precise, accurate, and economical. The medications in the combined formulation were analyzed using the zero-crossing point method. Lisinopril and amlodipine were discovered to have wavelengths of (204 and 240 nm) and (248 and 272 nm), respectively, in solvent medium in a concentration range of 5-45 μg mL-1 for lisinopril and 5-40 μg mL-1 for amlodipine. The results were much in line with the accepted methodology. Common tablet excipients showed no interference. the recovery rate of lisinopril dihydrate was 98.57 to 103.42% and amlodipine 95.14 to 102.80%. Amlodipine besylate and lisinopril dihydrate were satisfactorily measured using this technique in tablet forms.

Keywords

Amlodipine, Combined formulation, Lisinopril, Third derivative spectroscopy, Zero-crossing point

Subject Area

Chemistry

Article Type

Article

First Page

1124

Last Page

1130

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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