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Abstract

Rheumatoid Arthritis (RA) is a chronic, systemic autoimmune disease associated with synovial tissue proliferation, cartilage destruction and pannus formation. The study aimed to determine the link among each anticyvlic anti-citrullinated peptide antibody (ACPA), lactate dehydrogenase (LDH), zinc (Zn), and copper (Cu) levels in rheumatoid arthritis (RA) patients and healthy control. Across sectional study was carried out at the Baghdad Teaching Hospital in Baghdad Iraq, and involved 110 patients (95 females and 15 men), who were matched for age and sex with 40 healthy controls (28 females and 12 males). Patients with RA were diagnosed by a specialist rheumatologist utilizing ACR/EULAR criteria in 2010. According to the type of disease-modifying anti-rheumatic drug therapy used-biologic (bDMARDs), conventional (cDMARDs), and combined (DMARDs)-patients in this study were split into three subgroups. Zn, Cu, and LDH were quantified using a spectrophotometer (AAS), whilst serum ACPA was assessed using an enzyme-linked immunosorbent assay (ELISA). The results showed that there was a significant rise in all subgroups of ACPAs (p

Keywords

Anti-Citrullinated Peptide Antibodies, Autoimmunity, Copper, Lactate dehydrogenase, Rheumatoid Arthritis (RA), Synovitis, Zinc

Subject Area

Chemistry

Article Type

Article

First Page

1143

Last Page

1150

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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