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Abstract

Diabetes mellitus causes damage to pancreatic β cells and oxidative stress due to an imbalance of oxidants and antioxidants in the body. Controlling hyperglycemia by administering conventional drugs and with long-term use carries the risk of side effects, so traditional treatment is recommended. Benalu Duku (Dendophthoe pentandra (L.) Miq) is a plant considered a parasite. However, it has the potential to be developed as a diabetes drug because it contains metabolites that can be used as drugs that come from nature. This study aims to test phytochemicals and examine the effect of ethanol extract of Benalu Duku leaves (EEBD) on superoxide dismutase (SOD) levels in streptozotocin-nicotinamide-induced diabetic white Wistar rats, blood glucose levels were also examined, as well as conducting histological analysis of pancreatic β cells. The results of the phytochemical examination showed that it contained alkaloids, flavonoids, glycosides, saponins, tannins, and triterpenoids. Research shows that giving EEBD for 28 days can significantly reduce blood glucose levels compared to the Na-CMC group. SOD levels also increased with respective values of 30.97 ± 0.84, 21.99 ± 0.61, 30.52 ± 1.30, 28.55 ± 1.30, 28.99 ± 0.95, and 29.00 ± 0.86 pg/mL. Pancreatic histology also showed differences between qualitative and quantitative, indicating pancreatic repair and increased surface area of the islets of Langerhans. This plant has the potential to be developed into a new medicinal ingredient that comes from nature.

Keywords

Dendrophthoe pentandra, Diabetic, Hematoxylin-eosin, Langerhans, Pancreatic, Superoxide dismutase

Subject Area

Chemistry

Article Type

Article

First Page

1518

Last Page

1525

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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