Determination of chlorpheniramine maleate in its pharmaceutical preparations using homemade turbidity flow injection analyzer

Muntadhar M. Jabbar, Department of Chemistry, College of Education for Pure Science (Ibn Al-Haitham), University of Baghdad, Baghdad, IraqFollow
Elham N. Mezaal, Department of Chemistry, College of Education for Pure Science (Ibn Al-Haitham), University of Baghdad, Baghdad, IraqFollow

Abstract

By using continuous flow injection analysis technology, a new analytical method was presented for the determination of chlorpheniramine maleate (CPM) in its pure form and in some of its pharmaceutical preparations. The study was based on the reaction of CPM with ammonium ceric(IV) sulphate (ACS) in an acidic medium, where the reaction resulted in a slightly yellowish white precipitate. It was studied using Ayah 6S × 1-ST-2D solar cell CFI analyzer (homemade) by measuring the light reflected from the surfaces of precipitate particles at (0–180°). Several experiments were conducted to study and improve the chemical and physical parameters. The correlation coefficient (r) = 0.9996, and the linear calibration curve was within the range (0.07–5 mmol/L). The detection limit (L.O.D) was 195 ng/10 μL. The relative percentage deviation RSD% was less than 0.2% for the concentration of 1.0, 1.5 and 4.0 mmol/L of CPM for n = 8. The method was successfully applied in estimating CPM in three samples of pharmaceutical preparations available in the Iraqi pharmaceutical market for three different companies. The new method was compared with the UV–Vis spectrophotometric method at λ_max = 261 nm. To ensure that there was no significant difference between the proposed method and the spectrophotometric method, both a t-test and a F-test were conducted. The results of the two tests showed that there was no significant difference at the 95% confidence level, where the t-result was calculated (|-2.162). It is less than the t-tabular value (4.303) and also the calculated F value (31.9770) is less than the tabular F value.

Keywords

Antihistamines, chloropheniramine malate, CFI Analyzer, continuous flow injection, precipitate particles, UV-Vis spectrophotometric method

Subject Area

Chemistry

Article Type

Article

First Page

1451

Last Page

1464

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite this Article

Jabbar, Muntadhar M. and Mezaal, Elham N. (2025) "Determination of chlorpheniramine maleate in its pharmaceutical preparations using homemade turbidity flow injection analyzer," Baghdad Science Journal: Vol. 22: Iss. 5, Article 4.
DOI: https://doi.org/10.21123/bsj.2024.10244

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