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Abstract

A peptide called spexin (SPX) regulates blood glucose and lipid metabolism. The study primarily focused on the pathogenesis of type 2 diabetes mellitus (T2DM) in postmenopausal women, examining its relationship with serum SPX levels. A case-control study involved 180 postmenopausal women from Thi-Qar, Iraq were enrolled in the current study. Ninety women were recently diagnosed with diabetic postmenopausal women, while the other 90 were non-diabetic postmenopausal women. Blood samples were collected to test: Glycated hemoglobin (HbA1c), SPX, Malondialdehyde (MDA), Superoxide dismutase (SOD), C-reactive protein (CRP), fasting blood glucose (FSG), insulin, lipid profile and interleukein (IL-6). Results: FSG, HbA1c, insulin, and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), values raised significantly (P < 0.001) in T2DM postmenopausal women. Also, levels of MDA, CRP, and IL-6 dramatically elevated, and the levels of SPX and SOD significantly decreased (P < 0.001). Significant lipid profile changes were observed in postmenopausal T2DM subjects. Additionally, the connection in T2DM postmenopausal women showed a negative relationship between SPX with waist-to-height ratio, SPX with FSG, SPX with HOMA-IR, MDA with SPX, as well as a positive relationship between SPX and MDA, SPX and age, CRP and IL-6, CRP and age, IL-6 and FSG, SOD and insulin. It was demonstrated that SPX is crucial to the pathogenesis of T2DM in postmenopausal women. In diabetic individuals, targeting SPX may offer a novel strategy for preserving adequate glucose control.

Keywords

CRP, Malondialdehyde, Spexin, Superoxide dismutase, T2DM

Subject Area

Chemistry

Article Type

Article

First Page

1511

Last Page

1517

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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