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Abstract

Diabetics are twice as likely to experience high blood pressure as non-diabetics. Asprosin a protein hormone has 140 amino-acids, is secreted by white adipose-tissue in response to fasting. When the cAMP, protein kinase-A pathway is activated, it causes a fasting-induced increase in hepatic glucose release into the bloodstream. Irisin, a peptide consisting of 112 amino-acids, is produced by cleaving a protein in the plasma membrane to release an adipocytokine. Enhanced lipid and glucose metabolism, along with anti-inflammatory and antioxidant properties, are among the advantageous impacts of irisin. The purpose of this study is to determine the function of Asprosin and it's linked with irisin in individuals suffering from hypertension and type2diabetes. The study included 60 samples, ages 35--65, divided into two groups according to the diagnosis: T2DM patients and patients with hypertension, obtained from the Al-Yarmouk Hospital/Baghdad/Iraq, between June-February/2023. Some biochemical factors were measured for all study groups, which include: Fasting-glucose and lipid-profile were measured by the enzymatic-oxidation method. Using an enzymatic process, Asprosin, insulin, and irisin were measured with an enzyme-linked-immunosorbent-assay. Finally, Homeostasis-Model-Assessment-Insulin-Resistance was calculated according to the specific formula. The result showed a significance in BMI, WHR, irisin, FBS, HOMA-IR. Also, a positive correlation between irisin and Asprosin with BMI, FBS, and insulin. Finally, based on the ROC curve, Asprosin and irisin levels have a high diagnostic value for T2DM and hypertension respectively. From these findings, it is possible to assess the degree of hypertension and T2DM using the Asprosin or irisin level as a biomarker.

Keywords

Asprosin, Diabetes mellitus, Hypertension, Insulin resistance, Irisin, T2DM

Subject Area

Chemistry

Article Type

Article

First Page

2246

Last Page

2253

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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