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Abstract

Diabetic nephropathy (DN) is a serious kidney complication that can occur in individuals with diabetes; around 20% to 30% of individuals with Type 2 diabetes (T2D) develop diabetic nephropathy (DN), which is a persistent microvascular complication. The DN is often considered the leading contributor to end-stage renal failure. This study aimed to assess decorin levels and their correlation with various biochemical variables among three different groups: 40 patients with T2DM nephropathy (G1), 40 patients with T2DM without nephropathy (G2), and a healthy control group (G3). The study included a total of 120 participants, divided into three groups T2DM with DN (G1), T2DM without DN (G2), and healthy control group (G3) which is consisted of 40 males and 40 females, with ages ranging from 35 to 63 years. The participants were recruited from patients attending the AL-Kindi teaching hospital in Baghdad, Iraq. Data collected from participants revealed a substantial and statistically significant increase (P ≤ 0.01) in the levels of fasting blood glucose (FBG), insulin, homeostatic model assessment for insulin resistance (HOMA-IR), blood urea (B.urea), blood urea nitrogen percentage (BUN%), serum creatinine (S.creatinin), and uric acid. The results indicated that there was a highly significant increase (P ≤ 0.01) in decorin, insulin and HOMA-IR levels in G1 group compared to G2 and G3 groups. . In conclusion, positive correlation coefficients between decorin levels and insulin, HOMA-IR in both the TD2M with and without DN. This suggests that decorin levels play an essential role in the pathophysiology of diabetic patients.

Keywords

Decorin, Diabetic nephropathy, Insulin resistance, Kidney function test, T2DM

Subject Area

Chemistry

Article Type

Article

First Page

2173

Last Page

2179

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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