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Abstract

Knee osteoarthritis (KOA), commonly known as degenerative joint disease, is frequently brought on by wear-and-tear articular cartilage loss that occurs over time and most often affects the elderly. Since cartilage is the main element that breaks down when OA occurs, its chemical components can be exploited to develop a sensitive biomarker to identify the beginning and progression of OA disease. The study aimed to evaluate and assess the alteration in the serum level of collagen type I C-telopeptide (CTX-1), and human cartilage glycoprotein (YKL-40) in serum samples obtained from (81) patients diagnosed with Knee Osteoarthritis who were hospitalized in Baghdad Hospital in Baghdad Medical City, from April 2023 to July 2023. The laboratory test results were compared concerning this group and a group of healthy individuals (40). A statistically significant difference was found in the level of CTX-1, YKL-40, HDL, LDL, VLDL, TG, and cholesterol in patients with Knee Osteoarthritis compared to the control group. At the same time, there was no statistically significant difference between the two groups in BMI, Calcium ion, and ESR. According to the binary logistic regression analysis a statistically significant correlation was shown between the prevalence of KOA and CTX-1, YKL-40. Under the results of the ROC curve, CTX-1 exhibited an area under the curve (AUC) of 1.00, in YKL-40 was 0.994 in people with KOA. In conclusion, the serum levels of CTX-1, and YKL-40 can be regarded as trustworthy markers that can reliably be used to diagnose KOA patients.

Keywords

Age, CTX-1, Knee osteoarthritis, Lipid profile, YKL-40

Subject Area

Chemistry

Article Type

Article

First Page

2203

Last Page

2213

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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