•  
  •  
 

Abstract

This study focuses on the synthesis, structural analysis and antibacterial properties of a composite comprising hydroxyapatite (HAp), polyethylene glycol (PEG) and chitosan (CTS). CTS was extracted from shrimp shells, and CaO for Hap was obtained from pensi shell. These composites were synthesized using the sol-gel method in situ by varying the concentrations of PEG (5, 10, 15, 20 and 25%) and CTS (1, 2, 3, 4, and 5%). The synthesized composites were characterized using FTIR, XRD, SEM-EDX, and TGA-DTA analyses, and their antimicrobial activities were also evaluated. The HAp-PEG-Chitosan composite with 5% chitosan and 10% PEG was identified as the best product as a white powder. FTIR analysis revealed the presence of specific functional groups: PO43– and OH from HAp, N-H from chitosan, and C-H and C-C from PEG, confirming the successful formation of the composite. XRD analysis showed a hexagonal structure consistent with the hydroxyapatite diffraction standard (ICSD \#157481) and a reduction in crystallinity due to polymer addition. SEM analysis demonstrated that needle-like HAp derived from pensi shells underwent surface changes, resulting in a more uniform texture when combined with PEG. EDX analysis confirmed the presence of Ca, P, C, and O elements, validating the successful synthesis of the HAp-polymer composite. TG-DTA analysis showed weight loss below 200°C, indicating the thermal stability of PEG at this temperature. The antimicrobial activity of the HAp-PEG-Chitosan composite was tested against E. coli and S. aureus, with CIP antibiotics used as a positive control for comparison.

Keywords

Antimicrobial, Chitosan, Hydroxyapatite, In situ method, Polyethylene glycol

Subject Area

Chemistry

Article Type

Article

First Page

1464

Last Page

1472

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Download

Share

 
COinS