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Abstract

Vaginal candidiasis is an opportunistic fungal infection of the lower female reproductive tract caused by Candida species. This study aimed to investigate the roles of Enolase 1 and Interleukin-9 in the pathophysiology of vaginal candidiasis and examine their correlations with anthropometric and lipid profile parameters. A total of 120 participants were enrolled, including 80 patients with VC and 40 healthy controls. Patients were classified into Candida albicans and non-Candida albicans groups based on clinical and microbiological criteria. Serum and vaginal secretions levels of ENO-1 and IL-9 were measured using ELISA, while lipid profiles were assessed spectrophotometrically. Both ENO-1 and IL-9 levels were significantly higher in the serum and secretions of infected individuals compared to controls. A significant positive correlation was observed between serum IL-9 and ENO-1 in secretions within the C. albicans group. The combination of ENO-1 and IL-9 in vaginal secretions showed excellent diagnostic performance in distinguishing infected individuals from healthy ones, with AUC values approaching 1.00 in both the C. albicans and non-C. albicans groups. These findings support the potential of ENO-1 and IL-9 as dual biomarkers for the detection and monitoring of vaginal candidiasis, offering promising tools for improving diagnosis and guiding personalized treatment strategies.

Keywords

Candida albicans, Enolase-1, Interleukin-9, Non-C. albicans, Vaginal candidiasis

Subject Area

Biology

Article Type

Article

First Page

1527

Last Page

1538

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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