Abstract
The work successfully synthesized twelve novel derivatives of 4-imidazolidinone bearing a sulfadiazine moiety using a one-pot reaction. This was done by condensation of sulfadiazine with twelve different aldehydes to afford the corresponding imines as intermediates, which were then followed by a cyclization reaction with glycine to furnish the desired products 1-12 in 56-85% yields. The structures of these products were identified by FT-IR and 1H NMR spectroscopy. In addition, a number of the produced compounds demonstrated diverse antibacterial and antioxidant activities. In terms of the antibacterial activity, the compounds 1, 2, 3, 4, 5, 6, 8, 10, and 12 were tested. Compound 4 displayed the best inhibition against gram-negative bacteria (Escherichia coli), and compound 2 displayed the best inhibition against gram-positive bacteria (Staphylococcus aureus). In terms of the antioxidant activity, a few of the prepared compounds (2, 3, 4, 5, 8, and 12) were evaluated. The best-tested compound was 2 when compared to ascorbic acid with an IC50 value of 70.84.
Keywords
Antibacterial activities, Ascorbic acid, 4-Imidazolidinone, One-pot reaction, Sulfadiazine
Subject Area
Chemistry
Article Type
Article
First Page
2526
Last Page
2536
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
How to Cite this Article
Yousif, Sabaa A. and Dawood, Rafid S.
(2026)
"Functionalization of the Amine Group for Access to 4-Imidazolidinone-Sulfadiazine Hybrid Derivatives and Study of Their Biological Activities,"
Baghdad Science Journal: Vol. 23:
Iss.
7, Article 13.
DOI: https://doi.org/10.21123/2411-7986.5357
