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Abstract

Psoriasis is an autoimmune disease caused by T-cell activation. This condition is characterized by skin proliferation and inflammation. This study aimed to enhance tamanu oil bioavailability by green synthesis method, in order to evaluate the potential anti-psoriatic benefits of tamanu oil nanoemulsion in rat skin, based on observational, histopathological, and immunological outcomes. The formulation was prepared by phase inversion temperature technique. The physical and chemical characteristics include: droplet morphology, size, zeta potential, pH, and stability. The formulation exhibited a spherical and small globule size of less than 100 nm, good zeta potential (–23.9 mV), suitable pH (5.3) and physically stable. Twenty-six female albino rats were divided into four groups. A control group, an imiquimod group, imiquimod + tamanu oil nanoemulsion group, and imiquimod + clobetasol group. All groups except control, received imiquimod topically for a period of seven days. Only the third and fourth groups treated for a duration of six days. The phenotypical, immunological and histopathological impacts were evaluated. The inflammatory symptoms of psoriasis had been greatly decreased by this formulation.The results were firmed up by the observational, immunological and histopathological assessment. Tamanu oil nanoemulsion displaying effects comparable to clobetasol, suggesting its potential as a natural alternative with safer profile, due to its anti-inflammatory and antioxidant properties. The antipsoriatic mechanism of this formulation was mainly depended on the downregulation of tissue IL-17/IL-23 levels. Small globular size of the formulation improved skin penetration, alleviated the symptoms of psoriasis, reduced both the epidermal thickness and inflammatory cell infiltration.

Keywords

Histopathology of the skin, IL-17/IL-23, Imiquimod, Psoriasis, Tamanu oil nanoemulsion

Subject Area

Biology

Article Type

Article

First Page

2403

Last Page

2416

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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