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Abstract

Fatty tissue is considered an endocrine organ that produces a type of hormone called Adipokine; this hormone is specifically secreted by adipose tissues, such as asprosin. Polycystic Ovarian Syndrome (PCOS) is the most common hormonal condition throughout the years of reproduction in females, manifesting with a significant frequency of decreased glucose tolerance, increased serum androgen levels, and type 2 diabetes among female sufferers who are overweight or obese. The current investigation included 120 PCOS patients (40 obese, 40 normal weight) and 40 healthy women; samples were collected from July to December 2024 at Kamal al-Samarrai Hospital in Baghdad, Iraq. Serum asprosin levels were assessed via the enzyme-linked immunosorbent assay (ELISA) technique. Body mass index (BMI), waist circumference, follicle-stimulating hormone (FSH), testosterone, estradiol, insulin, HOMA-IR, and luteinizing hormone (LH) levels were analyzed. The data were analyzed with Origin Lab software version 25; inter-group comparison was done using ANOVA. The study revealed that obese PCOS women had a greater mean ± S.D BMI, waist circumference, asprosin, LH, fasting blood sugar (FBS), insulin, and insulin resistance (IR) in contrast to PCOS females with a normal weight and the control group. Conversely, the control group had a greater mean ± S.D of FSH compared to the normal weight and overweight PCOS females. In conclusion, PCOS patients had higher concentrations of asprosin than healthy women; elevated asprosin levels are the main factor responsible for insulin resistance in PCOS females.

Keywords

Asprosin, Infertility, Insulin resistance, Obesity, PCOS

Subject Area

Biology

Article Type

Article

First Page

2417

Last Page

2424

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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